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The Role of the Aversive Effects of Drugs in Self-Administration: Assessing the Balance of Reward and Aversion in Drug-Taking Behavior.

The role of the aversive effects of drugs in self-administration: assessing the balance of reward and aversion in drug-taking behavior. Behav Pharmacol. 2013 Jul 16; Verendeev A, Riley AL Since the first experimental demonstration that a drug of abuse supports… Continue reading

Mutation in Ribosomal Protein S5 Leads to Spectinomycin Resistance in Neisseria Gonorrhoeae.

Mutation in ribosomal protein S5 leads to spectinomycin resistance in Neisseria gonorrhoeae. Front Microbiol. 2013; 4: 186Ilina EN, Malakhova MV, Bodoev IN, Oparina NY, Filimonova AV, Govorun VM Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence… Continue reading

MOR Is Not Enough: Identification of Novel Mu-Opioid Receptor Interacting Proteins Using Traditional and Modified Membrane Yeast Two-Hybrid Screens.

...  tensin homolog (PTEN) in 248 primary DLBCL patient samples. These analyses revealed that loss of PTEN was detectable in 55% of germinal center B-cell-like (GCB) DLBCLs, whereas this abnormality was found in only 14% of non-GCB DLBCL patient samples.… Continue reading

Potential Use of Custirsen to Treat Prostate Cancer.

Potential use of custirsen to treat prostate cancer. Onco Targets Ther. 2013; 6: 785-97Higano CS Over the last few years, five agents have demonstrated a survival benefit over a comparator treatment or placebo in the treatment of metastatic castration-resistant prostate… Continue reading

Effectiveness of Massage Therapy on the Mood of Patients After Open-Heart Surgery.

...  and dopamine reuptake inhibitor; it is effective in the treatment of patients with major depression.To investigate the in vitro effects of WB in human cultured peripheral blood lymphocytes and human cortical neural (HCN2) cell lines, micronucleus, sister chromatid… Continue reading

Preventive Effects of Curcumin Against Drug- and Starvation-Induced Gastric Erosions in Rats.

...  trial termination is the liver toxicity induced by chemotherapeutic agents. Treatment with anticancer drugs like CB 1954 (5-(Aziridin-1-yl)-2,4-dinitrobenzamide) is associated with significant hepatotoxicity. Thymoquinone (TQ), extracted from Nigella sativa, is reported to possess anticancer and hepatoprotective effects. The aims… Continue reading

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay.

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science. 2013 Jul 5; 341(6141): 84-7Molina DM, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P The efficacy of… Continue reading

Gene and microRNA Expression Reveals Sensitivity to Paclitaxel in Laryngeal Cancer Cell Line.

...  and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. Int J Clin Exp Pathol. 2013; 6(7): 1351-61Xu CZ, Xie J, Jin B, Chen XW, Sun ZF, Wang BX, Dong P Paclitaxel is a widely used… Continue reading

Chlorprothixene in Bodies After Exhumation.

...  Jul 3; 105(13): 968-977Ahmed AU, Thaci B, Tobias AL, Auffinger B, Zhang L, Cheng Y, Kim CK, Yunis C, Han Y, Alexiades NG, Fan X, Aboody KS, Lesniak MS Oncolytic adenoviral virotherapy (OV) is a highly promising approach for… Continue reading

Angiogenesis Inhibitor Bevacizumab Increases the Risk of Ischemic Heart Disease Associated With Chemotherapy: A Meta-Analysis.

Angiogenesis Inhibitor Bevacizumab Increases the Risk of Ischemic Heart Disease Associated with Chemotherapy: A Meta-Analysis. PLoS One. 2013; 8(6): e66721Chen XL, Lei YH, Liu CF, Yang QF, Zuo PY, Liu CY, Chen CZ, Liu YW Concerns have arisen regarding the… Continue reading