Effectiveness of Massage Therapy on the Mood of Patients After Open-Heart Surgery.

Effectiveness of massage therapy on the mood of patients after open-heart surgery.

Iran J Nurs Midwifery Res. 2012 Feb; 17(2 Suppl 1): S120-4
Babaee S, Shafiei Z, Sadeghi MM, Nik AY, Valiani M

Cardiovascular diseases have the highest death rates in human society. Coronary artery disease is among the most important of these diseases. No treatment of cardiovascular disease has as much impact on the quality of life of the patients as the heart surgery. The recovery from heart surgery is associated with symptoms of pain and psychological distress. In the early recovery period, the patients will face moderate symptoms of anxiety and depression. In this regard, various measures of nursing, as complementary therapy practices have been performed to help the patients for overcoming the physical and psychological needs. One of these methods, in recent years has been the use of complementary and alternative therapies, particularly massage therapy, after heart surgery. Thus, the aim of this study was to determine the effectiveness of massage therapy on the mood of patients after open-heart surgery in Isfahan Chamran Hospital during 2010-11.In this study 72 patients, who underwent coronary artery bypass surgery, were selected. They were randomly assigned to the two case and control groups. The patients of the case group (n = 36) received Swedish massage for 20 minutes in 4 sessions in 4 consecutive days, 3 to 6 days after the open-heart surgery. The patients in the control group received only the routine care. The mood questionnaire (POMS) which was used in this study has been completed the day before the start of the study and intervention and again after the last day of the intervention. SPSS software version 12 and descriptive and inferential statistical methods were used for data analysis.The comparison of study results showed that massage decreased the overall rating of the patients’ mood after the surgery.The use of massage therapy as an effective nursing intervention can improve the patients’ mood after open-heart surgery. Due to the low cost and simplicity of this method, it can perhaps be used as a complement to drug therapy and postoperative interventions used in these patients. HubMed – depression


An investigation on the effect of strength and endurance training on depression, anxiety, and C-reactive protein’s inflammatory biomarker changes.

J Res Med Sci. 2012 Nov; 17(11): 1072-6
Khorvash M, Askari A, Rafiemanzelat F, Botshekan M, Khorvash F

This study is performed to investigate the effect of strength and endurance training on the levels of depression, anxiety, and C-reactive proteins inflammatory biomarker changes.The research method was experimental, and the statistical population is formed of 300 volunteer male students. After the pre-test, 120 subjects with notable depression and anxiety levels obtained from Beacke and Ketel’s questionnaires were selected and randomly divided into two groups of strength and endurance, each containing 60 subjects, and then, again into two groups of experimental and control, each with 30 subjects. All 120 subjects were blood-sampled in the first stage to determine CRP concentration. After 20 sessions of strength and endurance exercises again depression, anxiety, and C-reactive proteins testes were used for both control and experimental groups. Ultimately, the obtained data were analyzed by using t-test in dependent and independent groups and covariance analysis in P ? 0.05 level.The results showed that the average of age is 25.1 ± 3.2, average of weight is 70.4 ± 8.4 and average of height is 169.8 ± 12.1, in the subjects. Also, the strength and endurance training had reduced the anxiety by 27% (P = .0001), depression by 37% (P = .0001) and C-reactive proteins by 20% (P = 0.0001), in the subjects.Regarding the different effects of training types on research variables, the results showed that the endurance training has a greater effect in reducing the depression, and strength training, in blood C-reactive proteins reduction, Although, no significant difference was observed between anxiety-reducing effects of strength and endurance training. HubMed – depression


Development and validation of a postpartum depression risk score in delivered women, Iran.

J Res Med Sci. 2012 Nov; 17(11): 1067-71
Maracy MR, Kheirabadi GR

Investigators describe a dramatic increase in the incidence of mood disorder after childbirth, with the largest risk in the 90 days after delivery. This study is designed to develop a relatively simple screening tool and validate it from the significant variables associated with postpartum depression (PPD) to detect delivered women at high risk of having PPD.In the cross-sectional study, 6,627 from a total of 7,300 delivered women, 2-12 months after delivery were recruited and screened for PPD. Split-half validation was used to develop the risk score. The training data set was used to develop the model, and the validation data set was used to validate the developed the risk factors of postpartum depression risk score using multiple logistic regression analysis to compute the ? coefficients and odds ratio (OR) for the dependent variables associated with possible PPD in this study. Calibration was checked using the Hosmer and Lemeshow test. A score for independent variables contributing to PPD was calculated. Cutoff points using a trade-off between the sensitivity and specificity of risk scores derived from PPD model using the Receiver Operating Characteristic (ROC) curve.The predicted and observed PPD were not different (P value = 0.885). The aROC with area under the curve (S.E.) of 0.611 (0.008) for predicting PPD using the suggested cut-off point of -0.702, the proportion of participants screening positive for PPD was 70.9% (sensitivity) (CI 95%; 69.5, 72.3) while the proportion screening negative was 60.1% (specificity) (CI 95%; 58.2, 62.1).Despite of the relatively low sensitivity and specificity in this study, it could be a simple, practical and useful screening tool to identify individual at high risk for PPD in the target population. HubMed – depression


Stress: Neurobiology, consequences and management.

J Pharm Bioallied Sci. 2013 Apr; 5(2): 91-7
Kumar A, Rinwa P, Kaur G, Machawal L

Stress, both physical and psychological, is attracting increasing attention among neuroresearchers. In the last 20 decades, there has been a surge of interest in the research of stress-induced manifestations and this approach has resulted in the development of more appropriate animal models for stress-associated pathologies and its therapeutic management. These stress models are an easy and convenient method for inducing both psychological and physical stress. To understand the behavioral changes underlying major depression, molecular and cellular studies are required. Dysregulation of the stress system may lead to disturbances in growth and development, and may this may further lead to the development of various other psychiatric disorders. This article reviews the different types of stress and their neurobiology, including the different neurotransmitters affected. There are various complications associated with stress and their management through various pharmacological and non-pharmacological techniques. The use of herbs in the treatment of stress-related problems is practiced in both Indian and Western societies, and it has a vast market in terms of anti-stress medications and treatments. Non-pharmacological techniques such as meditation and yoga are nowadays becoming very popular as a stress-relieving therapy because of their greater effectiveness and no associated side effects. Therefore, this review highlights the changes under stress and stressor and their impact on different animal models in understanding the mechanisms of stress along with their effective and safe management. HubMed – depression


Assessment of Potential In vitro Genotoxic and Cytotoxic Effects of Bupropion Hydrochloride (Wellbutrin) in Human Peripheral Lymphocytes and Human Cortical Neuron.

Toxicol Int. 2013 Jan; 20(1): 11-8
Bhattacharya SK, Nathawat LS, Damani P, Choksi AK, Banik A, Sinha K, Bhattacharya AS

Wellbutrin (bupropion hydrochloride; WB), an anti-depressant of the aminoketone class is new highly selective norepinephrine and dopamine reuptake inhibitor; it is effective in the treatment of patients with major depression.To investigate the in vitro effects of WB in human cultured peripheral blood lymphocytes and human cortical neural (HCN2) cell lines, micronucleus, sister chromatid exchange analysis, cellular viability, and comet assays were employed. The present study is to our knowledge, the first report on WB genotoxicity in cultured human peripheral blood lymphocytes and its cytotoxicity in the HCN2 cell line. We have also investigated the genotoxic potential of WB to induce chromosomal aberrations.WB-induced cytotoxicity (measured as reduction of the nuclear division index) possibly prevented the division of damaged cells.We conclude that although, WB exerts potential genotoxic effects in cultured lymphocytes, its cytogenetic effects are very unlikely to occur in blood cultures of WB-administered subjects. HubMed – depression