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Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-Ones.

Published July 9, 2013

Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-ones.

Sci Pharm. 2013 Jun; 81(2): 393-422
El-Tombary AA

In the present investigation, some new pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives (7-12) as well as fused pyrazolo[3′,4′:4,5]pyrimido[1,2-b]pyridazin-4(1H)-one (14-16) and 7,8,9,10-tetrahydropyrazolo[3′,4′:4,5]pyrimido[1,2-b]-cinnolin-4(1H)-one (17) ring systems… Continue reading →

Ketamine for Treatment-Refractory Depression – Video Interview With James Murrough, MD

Published July 9, 2013

Ketamine for Treatment-Refractory Depression – Video Interview with James Murrough, MD –

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"Depression is so prevalent. About 30 percent of college kids have depression, and 80 percent of those don't get any treatment. The numbers are… Continue reading →

Kinetic Factors of Vertical Jumping for Heading a Ball in Flexible Flatfooted Amateur Soccer Players With and Without Insole Adoption.

Published July 6, 2013

Kinetic factors of vertical jumping for heading a ball in flexible flatfooted amateur soccer players with and without insole adoption.

Prosthet Orthot Int. 2013 Jul 4;
Arastoo AA, Aghdam EM, Habibi AH, Zahednejad S

Background:According to literature, little is known regarding the effects of orthotic management of flatfoot on kinetics of vertical jump.Objectives:To compare the kinetic and temporal events of two-legged vertical jumping take-off from a force plate for heading a ball in normal and flexible flatfoot subjects with and without insole.Study design:A functional based interventional controlled study.Methods:Random sampling method was employed to draw a control group of 15 normal foot subjects to a group of 15 flatfoot subjects. A force platform was used to record kinetics of two-legged vertical jump shots.Results:Results indicate that insole did not lead to a significant effect on kinetics regarding anterior-posterior and mediolateral directions (p > 0.05). Results of kinetics related… Continue reading →

Gene and microRNA Expression Reveals Sensitivity to Paclitaxel in Laryngeal Cancer Cell Line.

Published July 5, 2013

Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.

Int J Clin Exp Pathol. 2013; 6(7): 1351-61
Xu CZ, Xie J, Jin B, Chen XW, Sun ZF, Wang BX, Dong P

Paclitaxel is a widely… Continue reading →

Comparison of Proxy Ratings of Main Family Caregivers and Physicians on the Quality of Dying of Terminally Ill Cancer Patients.

Published July 4, 2013

Comparison of Proxy Ratings of Main Family Caregivers and Physicians on the Quality of Dying of Terminally Ill Cancer Patients.

Jpn J Clin Oncol. 2013 Jun 30;
Cheng SY, Dy S, Huang SB, Chen CY, Chiu TY

Proxy data… Continue reading →

Diet-Related Practices and BMI Are Associated With Diet Quality in Older Adults.

Published July 3, 2013

Diet-related practices and BMI are associated with diet quality in older adults.

Public Health Nutr. 2013 Jul 2; 1-5
Ford DW, Hartman TJ, Still C, Wood C, Mitchell D, Hsiao PY, Bailey R, Smiciklas-Wright H, Coffman DL, Jensen GL… Continue reading →

Angiogenesis Inhibitor Bevacizumab Increases the Risk of Ischemic Heart Disease Associated With Chemotherapy: A Meta-Analysis.

Published July 3, 2013

Angiogenesis Inhibitor Bevacizumab Increases the Risk of Ischemic Heart Disease Associated with Chemotherapy: A Meta-Analysis.

PLoS One. 2013; 8(6): e66721
Chen XL, Lei YH, Liu CF, Yang QF, Zuo PY, Liu CY, Chen CZ, Liu YW

Concerns have arisen… Continue reading →

Crofelemer: A Review of Its Use in the Management of Non-Infectious Diarrhoea in Adult Patients With HIV/AIDS on Antiretroviral Therapy.

Published June 29, 2013

Crofelemer: A Review of its Use in the Management of Non-Infectious Diarrhoea in Adult Patients with HIV/AIDS on Antiretroviral Therapy.

Drugs. 2013 Jun 27;
Frampton JE

Crofelemer (Fulyzaq™) is a botanical drug substance (oligomeric proanthocyanidin) extracted from the stem… Continue reading →

Prospects for Circumventing Aminoglycoside Kinase Mediated Antibiotic Resistance.

Published June 28, 2013

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.

Front Cell Infect Microbiol. 2013; 3: 22
Shi K, Caldwell SJ, Fong DH, Berghuis AM

Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in… Continue reading →

Evaluation of Different Screening Methods to Understand the Dissolution Behaviors of Amorphous Solid Dispersions.

Published June 27, 2013

Evaluation of different screening methods to understand the dissolution behaviors of amorphous solid dispersions.

Drug Dev Ind Pharm. 2013 Jun 26;
Lee TW, Boersen NA, Yang G, Hui HW

Abstract Objective: The objectives of the current study were to… Continue reading →