cancer cell

Correction of Drug-Induced Hepatotoxicity With New Triterpene Derivatives in Transplanted RLS Lymphoma.

Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma.

Bull Exp Biol Med. 2012 Dec; 154(3): 370-374
Zhukova NA, Semenov DE, Bessergeneva EP, Sorokina IV, Tolstikova TG

The hepatoprotective effects of new triterpene derivatives, betulin 3?,28-di-O-nicotinate… Continue reading

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

J Biomol Screen. 2013 Mar 11;
Duong-Thi MD, Bergström M, Fex T, Svensson S, Ohlson S, Isaksson R

In early drug discovery (e.g., in fragment screening), recognition of… Continue reading

Efficient Generation of Stable Bispecific IgG1 by Controlled Fab-Arm Exchange.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Proc Natl Acad Sci U S A. 2013 Mar 11;
Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen… Continue reading

Generation and Validation of a Zebrafish Model of EAST (Epilepsy, Ataxia, Sensorineural Deafness and Tubulopathy) Syndrome.

Generation and validation of a zebrafish model of EAST (Epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome.

Dis Model Mech. 2013 Feb 14;
Mahmood F, Mozere M, Zdebik AA, Stanescu HC, Tobin J, Beales PL, Kleta R, Bockenhauer D, Russell… Continue reading

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/?-Catenin Signaling in Cancer Cells.

The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/?-Catenin Signaling in Cancer Cells.

PLoS One. 2013; 8(2): e58102
Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y

While… Continue reading

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 Against LNCaP and PC3 Human Prostate Cancer Cells.

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 against LNCaP and PC3 Human Prostate Cancer Cells.

PLoS One. 2013; 8(3): e58267
Laurenzana A, Balliu M, Cellai C, Romanelli MN, Paoletti F

Histone deacetylase inhibitors (HDACi) represent a promising class of… Continue reading

Cytochrome P450 2E1 Gene Polymorphisms/Haplotypes and Anti-Tuberculosis Drug-Induced Hepatitis in a Chinese Cohort.

Cytochrome P450 2E1 Gene Polymorphisms/Haplotypes and Anti-Tuberculosis Drug-Induced Hepatitis in a Chinese Cohort.

PLoS One. 2013; 8(2): e57526
Tang S, Lv X, Zhang Y, Wu S, Yang Z, Xia Y, Tu D, Deng P, Ma Y, Chen D, Zhan… Continue reading

Future Prospects for Pharmacogenetics in the Quest for Personalized Medicine.

Future prospects for pharmacogenetics in the quest for personalized medicine.

J Psychosoc Nurs Ment Health Serv. 2012 Dec; 50(12): 13-6
Howland RH

Understanding pharmacogenetic differences in drug response and tolerability has been an important area of research in personalized… Continue reading

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.

PLoS One. 2013; 8(2): e56284
Lee YR, Yu DS, Liang YC, Huang KF, Chou SJ, Chen TC, Lee CC,… Continue reading

The Combined Propranolol/TSST Paradigm – a New Method for Psychoneuroendocrinology.

The Combined Propranolol/TSST Paradigm – A New Method for Psychoneuroendocrinology.

PLoS One. 2013; 8(2): e57567
Andrews J, Pruessner JC

Upon perception of a stimulus as stressful, the human brain reacts with the activation of the hypothalamus-pituitary-adrenal (HPA) axis and… Continue reading