[Rehabilitation in Axial Spondyloarthritides].
[Rehabilitation in axial spondyloarthritides].
Filed under: Rehab Centers
Rehabilitation (Stuttg). 2013 Feb; 52(1): 51-62
Mau W, Ehlebracht-König I
[CME: Certified Professional Development in Rehabilitation].
Filed under: Rehab Centers
Rehabilitation (Stuttg). 2013 Feb; 52(1): 1
Schliehe F, Mau W
Propyl gallate inhibits TPA-induced inflammation via the nuclear factor-?B pathway in human THP-1 monocytes.
Filed under: Rehab Centers
Exp Ther Med. 2013 Mar; 5(3): 964-968
Hsu HC, Lin WC, Chang PJ, Hong CZ, Chen CH
Propyl gallate (PG) is an antioxidant that has been used as an additive in several foods to protect against oxidation. The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes. Pretreatment with PG markedly inhibited the TPA-induced expression levels of cyclooxygenase-2 and prostaglandin E2. The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor-?B (NF-?B) and phosphorylation of p65 (Ser536) in TPA-treated THP-1 cells. PG also inhibited the phosphorylation of I?B and I?B kinase. These results indicate that PG inhibits the inflammatory response by blocking the NF-?B signaling pathway in TPA-induced THP-1 monocytes. Therefore, PG may be useful as a therapeutic agent in inflammatory diseases.
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