POSTPARTUM GAD IS a RISK FACTOR for POSTPARTUM MDD: THE COURSE and LONGITUDINAL RELATIONSHIPS of POSTPARTUM GAD and MDD.
POSTPARTUM GAD IS A RISK FACTOR FOR POSTPARTUM MDD: THE COURSE AND LONGITUDINAL RELATIONSHIPS OF POSTPARTUM GAD AND MDD.
Filed under: Depression Treatment
Depress Anxiety. 2013 Jan 3;
Prenoveau J, Craske M, Counsell N, West V, Davies B, Cooper P, Rapa E, Stein A
BACKGROUND: The objective was to examine the course and longitudinal associations of generalized anxiety disorder (GAD) and major depressive disorder (MDD) in mothers over the postpartum 2 years. METHOD: Using a prospective naturalistic design, 296 mothers recruited from a large community pool were assessed for GAD and MDD at 3, 6, 10, 14, and 24 months postpartum. Structured clinical interviews were used for diagnoses, and symptoms were assessed using self-report questionnaires. Logistic regression analyses were used to examine diagnostic stability and longitudinal relations, and latent variable modeling was employed to examine change in symptoms. RESULTS: MDD without co-occurring GAD, GAD without co-occurring MDD, and co-occurring GAD and MDD, displayed significant stability during the postpartum period. Whereas MDD did not predict subsequent GAD, GAD predicted subsequent MDD (in the form of GAD + MDD). Those with GAD + MDD at 3 months postpartum were significantly less likely to be diagnosis free during the follow-up period than those in other diagnostic categories. At the symptom level, symptoms of GAD were more trait-like than those of depression. CONCLUSIONS: Postpartum GAD and MDD are relatively stable conditions, and GAD is a risk factor for MDD but not vice versa. Given the tendency of MDD and GAD to be persistent, especially when comorbid, and the increased risk for MDD in mothers with GAD, as well as the potential negative effects of cumulative exposure to maternal depression and anxiety on child development, the present findings clearly highlight the need for screening and treatment of GAD in addition to MDD during the postpartum period.
HubMed – depression
Self-efficacy for coping with cancer in melanoma patients: its association with physical fatigue and depression.
Filed under: Depression Treatment
Psychooncology. 2013 Jan 3;
Albrecht K, Droll H, Giesler JM, Nashan D, Meiss F, Reuter K
OBJECTIVE: The purpose of this study was to explore the impact of self-efficacy for coping with cancer (SECC) on physical fatigue and depressive symptoms in melanoma patients, in comparison with objective factors, such as treatment with interferon-alpha (IFN-?) and medical and sociodemographic variables. Current literature shows that psychological distress in melanoma patients is generally moderate, that they experience high quality of life, and that symptoms of depression and fatigue have been mostly associated with adjuvant IFN-? treatment METHODS: A total of 175 melanoma patients, stages Ib-IIIc with and without low-dose IFN-? therapy, completed surveys on SECC, depression, and fatigue. Two hierarchical regression analyses were conducted to explore the predictive role of objective factors (first step: tumor stage, time since diagnosis, and current IFN-? treatment; second step: age and gender) in conjunction with the subjective factor of SECC (third step) on physical fatigue and depression. RESULTS: Regression analysis revealed no significant effect of IFN-? treatment upon depression. Current IFN-? treatment was predictive of higher fatigue scores, however. The highest predictive effect by far was obtained for SECC, indicating higher fatigue and depression in patients with lower SECC. CONCLUSIONS: The findings suggest that the treatment with IFN-? is mainly accompanied by physical fatigue in melanoma patients rather than by mood changes. Most notably, the potential influence of increased SECC on reducing both physical fatigue and depression is suggested by the data, indicating the importance of self-efficacy enhancing interventions in the psycho-oncological support of melanoma patients. Copyright © 2013 John Wiley & Sons, Ltd.
HubMed – depression
DUST FROM HOG CONFINEMENT FACILITIES IMPAIRS Ca2+ MOBILIZATION FROM SARCO(ENDO)PLASMIC RETICULUM BY INHIBITING RYANODINE RECEPTORS.
Filed under: Depression Treatment
J Appl Physiol. 2013 Jan 3;
Tian C, Moore CJ, Dodmane P, Shao CH, Romberger DJ, Toews ML, Bidasee KR
Individuals working in commercial hog confinement facilities have elevated incidences of headaches, depression, nausea, skeletal muscle weakness, fatigue, gastrointestinal disorders and cardiovascular diseases, and the molecular mechanisms for these non-respiratory ailments remain incompletely undefined. A common element underlying these diverse pathophysiologies is perturbation of intracellular Ca(2+) homeostasis. This study assessed whether the dust generated inside hog confinement facilities contains compounds that alter Ca(2+) mobilization via ryanodine receptors (RyRs), channels through which Ca(2+) leave the sarco(endo)plasmic reticulum to elicit an array of physiologic functions. Hog barn dust (HBD) was extracted with phosphate-buffered saline, sterile filtered (0.22 µm) and size-separated using Sephadex G-100 resin. Fractions 1 through 9 (M(w) >10,000 Da) had no measurable effects on RyR isoforms. However, F10 through F17, which contained compounds of M(w) ?2000 Da, modulated the [(3)H]ryanodine binding to RyR1, RyR2 and RyR3 in a biphasic (Gaussian) manner. The K(i) values for F13, the most potent fraction, were 3.8 ± 0.2 µg/ml for RyR1, 0.2 ± 0.01 ?g/ml and 19.1 ± 2.8 µg/ml for RyR2 (two binding sites), and 44.9 ± 2.8 µg/ml and 501.6 ± 9.2 ?g/ml for RyR3 (two binding sites). In lipid bilayer assays, F13 dose-dependently decreased the open probabilities of RyR1, RyR2, and RyR3. Pre-treating differentiated mouse skeletal myotubes (C2C12 cells) with F13 blunted the amplitudes of ryanodine- and K(+)-induced Ca(2+) transients. Since RyRs are present in many cell types, impairment in Ca(2+) mobilization from internal stores via these channels is a possible mechanism by which HBD may trigger these seemingly unrelated pathophysiologies.
HubMed – depression
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