Metformin Ameliorates Methotrexate-Induced Hepatotoxicity.

Metformin ameliorates methotrexate-induced hepatotoxicity.

Filed under: Drug and Alcohol Rehabilitation

J Pharmacol Pharmacother. 2012 Jul; 3(3): 248-53
Hadi NR, Al-Amran FG, Swadi A

To study the effect of metformin on amelioration of hepatotoxicity induced by methotrexate.After a 2-weeks of acclimatization period, the animals were randomly separated into three groups (seven rabbits each), all groups were maintained on standard chow diet throughout the experiment (8 weeks). Group 1 was treated with normal saline water (control), Group 2 with methotrexate (MTX, hepatotoxic), and Group 3 with MTX plus metformin. Induction of hepatotoxicity was carried out by administration of MTX to the rabbit in a dose of 0.25 mg/kg /day i.m. for 8 weeks.The treatment with MTX to rabbits for 8 weeks resulted in significant changes in serum liver enzymes, as compared to the baseline group. SGOT, SGPT, ALP, and bilirubin were significantly increased (P < 0.001), while total serum protein was significantly decreased. Similarly, 8 weeks of MTX treatment produced significant (P < 0.001) prolongation in PT. PTT was not significantly changed. It was found that serum MDA levels and SOD activity were significantly increased (P < 0.001), while serum GSH levels were significantly decreased (P < 0.001). Adding metformin to MTX is found to be significantly (P < 0.001) reduced the liver function test and shortening of PT and a significant increase in TSP (P < 0.001).It can be concluded that administration of metformin restored the altered liver function parameters and produced significant improvement in liver histopathological findings. Therefore, this additive drug possesses hepatoprotection against MTX-induced hepatotoxicity. HubMed – drug


Impact of clinical pharmacist interventions on the cost of drug therapy in intensive care units of a tertiary care teaching hospital.

Filed under: Drug and Alcohol Rehabilitation

J Pharmacol Pharmacother. 2012 Jul; 3(3): 242-7
Lucca JM, Ramesh M, Narahari GM, Minaz N

To analyze clinical pharmacist interventions in the intensive care units (ICUs) setting of a tertiary care Indian hospital and to assess the pharmacoeconomic impact on drug-related problems (DRPs).A postgraduate clinical pharmacist reviewed drug prescriptions over a period of 7 months. Whenever a DRP is identified, it was discussed with a physician and appropriate suggestions were provided, later it was documented on a preprepared form. Clinical significance of each intervention was graded based on the predicted clinical outcome. Acceptance of the interventions is entirely at the discretion of the medical staff. Each intervention was analyzed with respect to potential cost saving and/or additional cost incurred to existing drug therapy. An independent clinical panel was convened, and all the interventions made by the intervening pharmacist were critically reviewed for potential cost savings.The intervening pharmacist made 117 recommendations, of which 94% was accepted by the medical professionals. The most frequent DRP identified was overdose (24%). The total net cost savings made was Rs. 77260.13 (USD 1796.73). This corresponds with Rs. 965.75 per patient and an annualized savings of Rs. 135205.22.Clinical pharmacist interventions had a significant impact on the cost of drug therapy and the patient outcome in intensive care settings of our hospital.
HubMed – drug


Comparative evaluation of adverse drug reaction reporting forms for introduction of a spontaneous generic ADR form.

Filed under: Drug and Alcohol Rehabilitation

J Pharmacol Pharmacother. 2012 Jul; 3(3): 228-32
Singh A, Bhatt P

Despite comprehensive and stringent phases of clinical trials and surveillance efforts, unexpected and serious adverse drug reactions (ADRs) repeatedly occur after the drug is marketed. ADR reporting is an important aspect of an efficient and effective pharmacovigilance program. Although Medwatch, Yellow Card, CDSCO form, etc. are the protocol forms of ADR collection and reports, a number of countries design and use their respective ADR forms. This review compares similarities and dissimilarities of 13 ADR forms of countries representing their geographical location. This study extracted 73 data elements mentioned in 13 different ADR forms. Only 13 elements were common. An ADR form of Malaysia and Canada covers the highest number of data 43, while Brazil falls to the opposite end with a number of 17 data elements in lieu with the Generic ADR Form. The result of this review highlights 58 data elements of the proposed generic ADR form which ensures that requisite reporting information essential for correct causality assessment of ADRs are included. The proposed “Generic ADR form” could be adopted worldwide mandatorily for reporting any/all ADRs associated with marketed drugs.
HubMed – drug



Bella Tunno Posh with Purpose Recap – Thank you for shopping selfishly to give selflessly and helping us get FANCY for Philanthropy! We raised over 100! Our first annual Posh with Purpose event was a tremendous success. We had over 400 people attend the event and the Mint Museum mentioned it was one of the largest events they can remember in a long time. 100% of the proceeds were donated to the CHARLOTTE RESCUE MISSION DOVE’S NEST PROGRAM, a drug and alcohol rehabilitation program for women. This revolutionary program keeps families together by providing on site housing for children of the clients as well as the women.


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