HTR2A-1438A/G Polymorphism Influences the Risk of Schizophrenia but Not Bipolar Disorder or Major Depressive Disorder: A Meta-Analysis.

HTR2A-1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: A meta-analysis.

Filed under: Depression Treatment

J Neurosci Res. 2013 Feb 13;
Gu L, Long J, Yan Y, Chen Q, Pan R, Xie X, Mao X, Hu X, Wei B, Su L

The incidence of psychiatric disorders has been shown to have a strong genetic component, and we conducted this study to investigate whether the -1438A/G polymorphism of the HTR2A gene was associated with susceptibility to schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using data obtained from a total 27 studies that investigated an association between the HTR2A -1438A/G polymorphism and SZ (15), BD (7), and MDD (4). We failed to observe an association between the HTR2A -1438A/G polymorphism and BD and MDD, and we found contrary results with regard to SZ. Our results showed that the -1438A/G polymorphism was a risk factor for SZ, especially in Caucasians (allele model: OR, 1.12; 95% CI, 1.05-1.20; I(2) = 17.3%; dominant model: OR, 1.14; 95% CI, 1.03-1.27; I(2) = 15.3%; recessive model: OR, 1.20; 95% CI, 1.06-1.37; I(2) = 0.0%; codominant model 1: OR, 1.16; 95% CI, 1.01-1.32; I(2) = 0.0%). We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD. © 2013 Wiley Periodicals, Inc.
HubMed – depression


Efficacy of Ocimum sanctum for Relieving Stress: A Preclinical Study.

Filed under: Depression Treatment

J Contemp Dent Pract. 2012; 13(6): 782-6
Bathala LR, Rao ChV, Manjunath S, Vinuta S, Vemulapalli R

History and objective: The aim of this study was to study the anxiolytic effects of Ocimum sanctum stress-induced anxiety. Materials and methods: The study was carried out using male albino rats (200 ± 50 gm), male albino mice (25 ± 100) the effect of O. sanctum evaluated for anxiety and depression using forced swim test FST and rotarod test. Results: Restraint stress (3 hours/day for six consecutive days) induced a significant reduction. It was significantly decreases the mobility period during stress. The standard deviation values are 14.4 and 9.26 and is statistically significant (p = 0.001). In rotarod test, (a) increased latency and (b) decreased ambulation and rearing were also reversed by O. sanctum. A significant increase in immobility period was observed in FST and TST after restraint stress. O. sanctum and C. sinensis significantly reduced the immobility times of rats in FST and TST. Conclusion: Ocimum sanctum possess significant antistress activity but the magnitude and efficacy for relieving stress is less, when compare to standard anxiolytic agent, i.e. Alprazolam. Keywords: Ocimum sanctum, Alprazolam, Immobility period, Latency period, Anti-stress. How to cite this article: Bathala LR, Rao CV, Manjunath SM, Vinuta S, Vemulapalli R. Efficacy of Ocimum sanctum for Relieving Stress: A Preclinical Study. J Contemp Dent Pract 2012;13(6):782-786. Source of support: Nil Conflict of interest: None declared.
HubMed – depression


Variability Over Time-Since- Diagnosis in the Protective Effect of Psychological Resilience Against Depression in Australian Prostate Cancer Patients: Implications for Patient Treatment Models.

Filed under: Depression Treatment

Am J Mens Health. 2013 Feb 11;
Sharpley CF, Wootten AC, Bitsika V, Christie DR

Although there is some evidence that psychological resilience may “buffer” against depression following major stressors, no data have been reported on the nature and variability of this buffering effect among prostate cancer patients during the 5 years following their initial diagnosis. Patients from two sites in Australia and who had received their initial diagnosis within 5 years (n = 255) were surveyed, and the results indicated that there was a significant inverse relationship between resilience and depression in the overall data, but that was mostly accounted for by a single factor of the resilience scale (“Confidence to cope with change”). Variability in that buffering effect was noted over time since diagnosis, with peaks during the first 6 months, at 24 and 60 months. These findings support the argument to develop focused psychiatric interventions at various periods following a diagnosis of prostate cancer.
HubMed – depression


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