How to Recognize a Patient Who’s High on “Bath Salts”.
How to recognize a patient who’s high on “bath salts”.
Filed under: Drug and Alcohol Rehabilitation
J Fam Pract. 2012 Apr; 61(4): 210-2
Penders TM
Forget about a routine drug screen; it won’t help. Here’s how these patients will present and how best to care for them.
HubMed – drug
Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.
Filed under: Drug and Alcohol Rehabilitation
Int J Alzheimers Dis. 2012; 2012: 518901
Cacabelos R, Martínez R, Fernández-Novoa L, Carril JC, Lombardi V, Carrera I, Corzo L, Tellado I, Leszek J, McKay A, Takeda M
Dementia is a major problem of health in developed societies. Alzheimer’s disease (AD), vascular dementia, and mixed dementia account for over 90% of the most prevalent forms of dementia. Both genetic and environmental factors are determinant for the phenotypic expression of dementia. AD is a complex disorder in which many different gene clusters may be involved. Most genes screened to date belong to different proteomic and metabolomic pathways potentially affecting AD pathogenesis. The ?4 variant of the APOE gene seems to be a major risk factor for both degenerative and vascular dementia. Metabolic factors, cerebrovascular disorders, and epigenetic phenomena also contribute to neurodegeneration. Five categories of genes are mainly involved in pharmacogenomics: genes associated with disease pathogenesis, genes associated with the mechanism of action of a particular drug, genes associated with phase I and phase II metabolic reactions, genes associated with transporters, and pleiotropic genes and/or genes associated with concomitant pathologies. The APOE and CYP2D6 genes have been extensively studied in AD. The therapeutic response to conventional drugs in patients with AD is genotype specific, with CYP2D6-PMs, CYP2D6-UMs, and APOE-4/4 carriers acting as the worst responders. APOE and CYP2D6 may cooperate, as pleiotropic genes, in the metabolism of drugs and hepatic function. The introduction of pharmacogenetic procedures into AD pharmacological treatment may help to optimize therapeutics.
HubMed – drug
Is there a role for hypolipidaemic drug therapy in the prevention or treatment of microvascular complications of diabetes?
Filed under: Drug and Alcohol Rehabilitation
Open Cardiovasc Med J. 2012; 6: 28-32
Mitsiou EK, Athyros VG, Karagiannis A, Mikhailidis DI
Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy.
Filed under: Drug and Alcohol Rehabilitation
Clin Dev Immunol. 2012; 2012: 257695
de Carvalho F, Vettore AL, Colleoni GW
Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.
HubMed – drug
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