Genetic Variants Associated With Disordered Eating.

Genetic variants associated with disordered eating.

Int J Eat Disord. 2013 Apr 9;
Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW, Martin NG

OBJECTIVE: Although the genetic contribution to the development of anorexia nervosa (AN) has long been recognized, there has been little progress relative to other psychiatric disorders in identifying specific susceptibility genes. Here, we have carried out a genome-wide association study on an unselected community sample of female twins surveyed for eating disorders. METHOD: We conducted genome-wide association analyses in 2,564 female twins for four different phenotypes derived from self-report data relating to lifetime presence of 15 types of disordered eating: AN spectrum, bulimia nervosa (BN) spectrum, purging via substances, and a binary measure of no disordered eating behaviors versus three or more. To complement the variant level results, we also conducted gene-based association tests using VEGAS software. RESULTS: Although no variants reached genome-wide significance at the level of p < 10(-8) , six regions were suggestive (p < 5 × 10(-7) ). The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype. DISCUSSION: As with other medical and psychiatric phenotypes, much larger samples and meta-analyses will ultimately be needed to identify genes and pathways contributing to predisposition to eating disorders. © 2013 by Wiley Periodicals, Inc. HubMed – eating


The efficacy of a brief group cbt program in treating patients diagnosed with bulimia nervosa: A brief report.

Int J Eat Disord. 2013 Apr 9;
Jones A, Clausen L

OBJECTIVE: The aim of the study was to evaluate the efficacy of a brief group cognitive behavior therapy (CBT) program in treating a large cohort of patients diagnosed with bulimia nervosa. METHOD: Treatment outcome defined as reductions in bulimia related behavioral symptoms and bulimia related distress was examined in 205 consecutive new patients enrolled in an eight-session group CBT program. RESULTS: Significant reductions in eating disorder pathology were found on all measures of bulimia related behavioral symptoms, as well as on all measures of bulimia related distress. DISCUSSION: There is strong evidence for the efficacy of brief group CBT in treating patients with bulimia nervosa. © 2013 by Wiley Periodicals, Inc. HubMed – eating


[Early nutritional determinants of fat-free mass in early adulthood: a systematic review].

Cad Saude Publica. 2013 Apr; 29(4): 639-53
Orlandi SP, Schneider BC, Gonzalez MC, González-Chica DA, Assunção MC

Early childhood nutritional factors can play a crucial role in the development of body composition in later phases of life. A systematic literature review was conducted to identify studies on the association between early nutritional determinants and fat-free mass in adulthood. The PubMed and Virtual Health Library electronic databases were used. Nine articles were included after a peer review of the 576 references initially found, published from 2003 to 2009, with healthy subjects and longitudinal analysis. Birth weight and birth length and variations across childhood were strong predictors of fat-free mass at later ages. The studies showed that higher birth weight and greater weight gain in early childhood were associated with greater fat-free mass in adulthood. However, the available data are limited and inconclusive in relation to eating in early childhood as a predictor of fat-free mass at later ages. HubMed – eating



Warning Signs of Eating Disorders – Dr. Johnson shares six warning signs about eating disorders — some that may be surprising! This film is created by NORMAL — a national nonprofit that colla…