FTO at Rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in Preschool Children.

FTO at rs9939609, Food Responsiveness, Emotional Control and Symptoms of ADHD in Preschool Children.

Filed under: Eating Disorders

PLoS One. 2012; 7(11): e49131
Velders FP, De Wit JE, Jansen PW, Jaddoe VW, Hofman A, Verhulst FC, Tiemeier H

The FTO minor allele at rs9939609 has been associated with body mass index (BMI: weight (kg)/height (m)(2)) in children from 5 years onwards, food intake, and eating behaviour. The high expression of FTO in the brain suggests that this gene may also be associated with behavioural phenotypes, such as impulsivity and control. We examined the effect of the FTO minor allele (A) at rs9939609 on eating behaviour, impulsivity and control in young children, thus before the BMI effect becomes apparent. This study was embedded in the Generation R Study, a population-based cohort from fetal life onwards. 1,718 children of European descent were genotyped for FTO at rs9939609. With logistic regression assuming an additive genetic model, we examined the association between the FTO minor allele and eating behaviour, impulsivity and control in preschool children. There was no relation between FTO at rs9939609 and child BMI at this age. The A allele at rs9939609 was associated with increased food responsiveness (OR 1.21, p?=?0.03). Also, children with the A allele were less likely to have symptoms of ADHD (OR 0.74, p?=?0.01) and showed more emotional control (OR 0.64, p?=?0.01) compared to children without the A allele. Our findings suggest that before the association between FTO and BMI becomes apparent, the FTO minor allele at rs9939609 leads to increased food responsiveness, a decreased risk for symptoms of ADHD and better emotional control. Future studies are needed to investigate whether these findings represent one single mechanism or reflect pleiotropic effects of FTO.
HubMed – eating


Liking food less: the impact of social influence on food liking evaluations in female students.

Filed under: Eating Disorders

PLoS One. 2012; 7(11): e48858
Robinson E, Higgs S

Social factors are known to influence food intake and choice. However, whether social influence acts on evaluations of food and drink liking has not been studied. Across two studies, we tested whether leading a participant to believe that other people do not like a food affects food liking evaluations. In Study 1, we exposed participants to social normative information suggesting a) that an in-group disliked orange juice, b) that an out-group disliked orange juice or c) that an in-group were neutral about orange juice. We then examined how much participants believed they liked orange juice. In Study 2, participants consumed a snack food before being led to believe that two previous participants had also eaten the food and either disliked or quite liked it. We asked participants to rate how much they had enjoyed eating the snack food. Across both studies, social influence was observed, as underlined by decreases in liking evaluations. In Study 1, beliefs about liking were only influenced by social normative information when the norm was expressed by an in-group. In Study 2, exposure to others’ accounts of a negative experience with a food decreased evaluated liking of the recent consumption experience. These results suggest that social influence can act upon food liking evaluations.
HubMed – eating


Changes of quality of life in gastric cancer patients after curative resection: a longitudinal cohort study in Korea.

Filed under: Eating Disorders

Ann Surg. 2012 Dec; 256(6): 1008-13
Kim AR, Cho J, Hsu YJ, Choi MG, Noh JH, Sohn TS, Bae JM, Yun YH, Kim S

: Little is known about how quality of life (QOL) changes over time after gastrectomy. We prospectively examined changes of QOL in Korean patients with gastric cancer after curative resection.: As early detection and improved treatment have led to higher survival rates and an increasing number of long-term survivors, the importance of QOL has increased.: Patients newly diagnosed with gastric cancer, who were expected to undergo curative resection, were studied. QOL was assessed, using the European Organization for Research and Treatment of Cancer QLQ-C30 and its gastric module QLQ-STO22, before and after 3 and 12 months of gastrectomy.: In total, 465 patients were included in the study, and 377 and 88 patients underwent subtotal gastrectomy and total gastrectomy, respectively. For most of the functional or symptom scales, the mean score deteriorated at 3 months and generally improved during follow-up period. Patients with total gastrectomy had more functional and symptomatic problems related to QOL than those with subtotal gastrectomy during the follow-up. For both groups, there were temporal, unrecovered, improved, and unchanged problems in QOL. Fatigue; digestive symptoms such as diarrhea, dysphagia, and eating restrictions; body image disturbance; and cognitive functioning were the representative unrecovered problems, which persisted at 12 months after surgery.: Our findings show that there are various functional and symptomatic problems, which health care providers need to manage during the postsurgical period. We need to continuously address fatigue, diarrhea, dysphagia, eating restrictions, body image disturbance, and cognitive functioning. In addition, it would be necessary to inform patients about possible QOL outcomes while they are receiving information about surgery and signing informed consent for surgery.
HubMed – eating


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