Fibrin Glue for Gundersen Flap Surgery.

Fibrin glue for Gundersen flap surgery.

Clin Ophthalmol. 2013; 7: 479-484
Chung HW, Mehta JS

To evaluate the feasibility of fibrin glue in Gundersen flap surgery.Prospective case series.Seven eyes of seven subjects who had undergone Gundersen flap surgery from 2009 to 2011 at the Singapore National Eye Centre, Singapore.Review of case records for outcomes after Gundersen flap surgery.Surgical success was defined as achieving a stable ocular surface. Complications to be noted included flap retraction or exposure of underlying corneal surface.Surgical success was achieved in all eyes with significant reduction in ocular surface inflammation. No retractions were noted and recovery was uncomplicated.Fibrin glue application is a viable alternative to sutures in Gundersen flap surgery. It reduces surgical downtime, gives faster ocular surface rehabilitation, and offers similar outcomes to conventional conjunctival flap surgery. HubMed – rehab


Local Metabolic Rate During Whole-Body Vibration.

J Appl Physiol. 2013 Mar 14;
Friesenbichler B, Nigg BM, Dunn JF

Background Whole-body vibration (WBV) platforms are currently used for muscle training and rehabilitation. However, the effectiveness of WBV training remains elusive, since scientific studies vary largely in the vibration parameters used. The origin of this issue may be related to a lack in understanding of the training intensity that is imposed on individual muscles by WBV. Therefore this study evaluates the training intensity in terms of metabolic rate of two lower extremity muscles during WBV under different vibration parameters. Methods Fourteen healthy male subjects were randomly exposed to 0 Hz (control), 10 Hz, 17 Hz and 28 Hz vibrations while standing upright on a vibration platform. A near-infrared spectrometer was used to determine the gastrocnemius medialis (GM) and vastus lateralis (VL) muscles’ metabolic rates during arterial occlusion. Results The metabolic rates during each vibration condition were significantly higher compared to control for both muscles (P < 0.05). Each increase in vibration frequency translated into a significantly higher metabolic rate than the previous lower frequency (P < 0.05) for both muscles. Conclusions The current study showed that the local metabolic rate during WBV at 28 Hz was on average 5.4 times (GM) and 3.7 times (VL) of the control metabolic rate. The substantial changes in local metabolic rate indicate that WBV may represent a significant local training stimulus for particular leg muscles. HubMed – rehab


Ccr2-64i and Ccr5 ?32 Polymorphisms in Patients with Late-Onset Alzheimer’s disease; A Study from Iran (Ccr2-64i And Ccr5 ?32 Polymorphisms in Alzheimer’s disease).

Iran J Basic Med Sci. 2012 7; 15(4): 937-944
Khorram Khorshid HR, Manoochehri M, Nasehi L, Ohadi M, Rahgozar M, Kamali R

Objective(s):Alzheimer’s disease (AD) is a complex disease with multifactorial etiology. Inflammation has been proven to have an important role in the pathogenesis of AD. Both CCR2 and CCR5 genes expression increase in AD patients comparing to control subjects. CCR5 gene encodes a protein which is a member of the beta chemokine receptors family of integral membrane proteins. CCR5-?32 is a genetic variant of CCR5 and is characterized by the presence of a 32-bp deletion in the coding region of the gene, which leads to the expression of a nonfunctional receptor, and the CCR2-64I has a change of valine to isoleucine at codon 64, in the first transmembrane domain. It has been proved that both genes have important roles in different stages of inflammation. Materials and Methods:The frequencies of CCR5?32 and CCR2-64I variations were determined in 156 AD patients and 161 control subjects using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, and the results were compared among AD and healthy controls. Results :Statistical analysis showed no significant difference in the distributions of CCR5?32 and CCR2-64I between the AD patients and healthy controls (P> 0.05). Stratifying the samples by gender, genetic background and presence of ApoE?4 allele showed no significant effect on the distributions of CCR5?32 and CCR2-64I (P> 0.05). Conclusion:Our study did not show an association between CCR5?32 and CCR2-64I variations and AD in the Iranian population. Further confirmatory studies with bigger number of samples are recommended. HubMed – rehab