Drug and Alcohol Rehabilitation: In Vitro Chloroquine Resistance in Plasmodium Falciparum Isolates From Tertiary Care Hospital.

In Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary Care Hospital.

Filed under: Drug and Alcohol Rehabilitation

Malar Res Treat. 2012; 2012: 538481
Shujatullah F, Khan HM, Khatoon A, Khan PA, Ashfaq M

Chloroquine (CQ) has been the mainstay of treatment of malaria for decades. This cost-effective and safe drug has become ineffective for treatment of falciparum malaria in many parts of the world due to development of resistance by the parasite. In addition CQ is not gametocytocidal for P. falciparum and thus cannot block transmission. The extent of problem of chloroquine resistance in P. falciparum is increasing every year. The study was done in period of 2 years. A total of 5653 specimens were examined for malarial infection by employing different diagnostic modalities. Four hundred and thirty-five were found to be positive for P. falciparum by using different diagnostic techniques. All positive specimens were cultured on RPMI 1640 medium; only 108 were found to be culture positive. Sensitivity of isolates to chloroquine was done using Mark III WHO sensitivity plates. The prevalence of malaria infection was found 9.54% in 2010. There were schizont formation at 8?pmol/liter or more of chloroquine concentration in 26 isolates. The emergence of chloroquine (CQ) resistance pattern in Aligarh isolates increases. Antimalarial agents should be used with caution; monotherapies should be avoided.
HubMed – drug


From the diabetic foot ulcer and beyond: how do foot infections spread in patients with diabetes?

Filed under: Drug and Alcohol Rehabilitation

Diabet Foot Ankle. 2012; 3:
Aragón-Sánchez J, Lázaro-Martínez JL, Pulido-Duque J, Maynar M

A diabetic foot infection is usually the result of a pre-existing foot ulceration and is the leading cause of lower extremity amputation in patients with diabetes. It is widely accepted that diabetic foot infections may be challenging to treat for several reasons. The devastating effects of hyperglycemia on host defense, ischemia, multi-drug resistant bacteria and spreading of infection through the foot may complicate the course of diabetic foot infections. Understanding the ways in which infections spread through the diabetic foot is a pivotal factor in order to decide the best approach for the patient’s treatment. The ways in which infections spread can be explained by the anatomical division of the foot into compartments, the tendons included in the compartments, the initial location of the point of entry of the infection and the type of infection that the patient has. The aim of this paper is to further comment on the existed and proposed anatomical principles of the spread of infection through the foot in patients with diabetes.
HubMed – drug


Sweet’s Syndrome Presenting in Concordance with Acute Coronary Syndrome.

Filed under: Drug and Alcohol Rehabilitation

J Clin Aesthet Dermatol. 2012 Sep; 5(9): 47-50
Kassardjian M, Holland V, Leong T, Horowitz D, Hirokane J

Acute febrile neutrophilic dermatosis (Sweet’s syndrome) is typically characterized by an acute onset of erythematous papules, plaques, and nodules in a febrile patient. This dermatosis is classically accompanied by leukocytosis and neutrophilia, and has had reported associations with various underlying etiologies including drug reactions, malignancies, infections, autoimmune disorders, and inflammatory bowel diseases. However, most cases of acute febrile neutrophilic dermatosis are idiopathic. We present a unique case of Sweet’s syndrome in a patient with concurrent acute myocardial infarction.
HubMed – drug



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