Drug and Alcohol Rehabilitation: Anti-Inflammatory and Antinociceptive Effects of Salbutamol on Acute and Chronic Models of Inflammation in Rats: Involvement of an Antioxidant Mechanism.

Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Filed under: Drug and Alcohol Rehabilitation

Mediators Inflamm. 2012; 2012: 438912
Uzkeser H, Cadirci E, Halici Z, Odabasoglu F, Polat B, Yuksel TN, Ozaltin S, Atalay F

The possible role of ?-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that the ?-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which result in oxidative stress. We hypothesized that salbutamol would prevent inflammatory and nociceptive responses by stimulating ?-2 adrenergic receptors and the prevention of generation of ROS during the acute inflammation process in rats. Both doses of salbutamol used in the study (1 and 2 mg/kg) effectively blocked the acute inflammation and inflammatory nociception induced by carrageenan. In the cotton-pellet-induced granuloma test, both doses of salbutamol also significantly decreased the weight of granuloma tissue on the cotton pellets when compared to the control. Anti-inflammatory and analgesic effects of salbutamol were found to be comparable with those of indomethacin. Salbutamol decreased myeloperoxidase (MPO) activity and lipid peroxidation (LPO) level and increased the activity of superoxide dismutase (SOD) and level of glutathione (GSH) during the acute phase of inflammation. In conclusion, salbutamol can decrease acute and chronic inflammation, possibly through the stimulation of ?-2 adrenergic receptors. This anti-inflammatory effect may be of significance in asthma treatment, where inflammation also takes part in the etiopathology. This study reveals that salbutamol has significant antioxidative effects, which at least partially explain its anti-inflammatory capabilities. These findings presented here may also shed light on the roles of ?-2 adrenergic receptors in inflammatory and hyperalgesic conditions.
HubMed – drug alcohol rehabilitation


[Hepatitis C! Experience in diagnosis and medical treatment. A literature review].

Filed under: Drug and Alcohol Rehabilitation

Pflege. 2012 Jun; 25(3): 185-95
Künzler-Heule P, Panfil EM

Chronic hepatitis C can have physical, psychological or emotional effects on a person. The chronic infection can result in an advanced liver disease and/or influence daily life and self-perception. Today, the possibility to eliminate the virus exists but the therapy is difficult, a decrease in quality of life is known. Anyway, the sustained viral response isn’t achievable for everyone. Care in Switzerland usually takes place in the outpatient clinics. Nurse participation to improve self-management is in discussion. For this specific work knowledge of patient’s perception is crucial. A literature review was done to answer two questions: “What is the experience of the illness ‘chronic hepatitis C’?” and additionally “What has to be managed when undergoing treatment?”. A literature search was conducted in the databases of Pubmed and CINAHL. Seven qualitative studies were included. Diagnosis, contagion, illness, stigmatisation and fatigue are central themes and can influence each other. Discussion about treatment and the decision for it seems to be ambiguous. Patients feel reduced to their disease and demand for individual interventions especially for their experience with their illness. A targeted assessment seems important to appreciate their needs in each situation.
HubMed – drug alcohol rehabilitation


Prevalence and correlates of mental health problems and treatment among adolescents seen in primary care.

Filed under: Drug and Alcohol Rehabilitation

J Adolesc Health. 2012 Jun; 50(6): 559-64
Burnett-Zeigler I, Walton MA, Ilgen M, Barry KL, Chermack ST, Zucker RA, Zimmerman MA, Booth BM, Blow FC

In this study, we describe the characteristics of adolescents with mental health problems among those presenting to primary care clinics in urban areas.The sample included 1,076 adolescents aged 12-18 years who presented to federally qualified community health clinics in urban cities in the Midwest. Bivariate and multivariate logistic regression analyses were conducted to examine the associations between having a mental health problem with demographic characteristics, health-related variables, and other risk and promotive factors. We also examined the use of health services and involvement in activities among those with mental health problems.Approximately 14% of adolescents screened positive for a mental health problem; among those with a mental health problem, 42.8% received mental health services in the past 3 months. In the multivariate logistic regression analysis, adolescents who were female, with poorer grades, fair to poor self-reported health, using drugs, and lower parental monitoring were more likely to have a mental health problem. In bivariate analyses, adolescents with mental health problems were less likely to participate in school activities and community activities and more likely to use emergency room services.Adolescents with mental health problems were more likely to have several other difficulties including poor grades, poor self-rated health, drug/alcohol use, and sexual activity. This study highlights the importance of screening youth with multidimensional needs and referring them to the appropriate services.
HubMed – drug alcohol rehabilitation


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