Diabetes Mellitus Is Linked to an Increased Risk of Developing Adhesive Capsulitis. a Longitudinal Population-Based Follow-Up Study.

Diabetes mellitus is linked to an increased risk of developing adhesive capsulitis. A longitudinal population-based follow-up study.

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Arthritis Care Res (Hoboken). 2012 Dec 21;
Huang YP, Fann CY, Chiu YH, Yen MF, Chen LS, Chen HH, Pan SL

OBJECTIVES: Although diabetes mellitus (DM) has been suggested as a risk factor of adhesive capsulitis of the shoulder (ACS), data on the temporal association between these two conditions are sparse. The purpose of this population-based, age- and sex- matched cohort study was to investigate the risk of developing ACS in patients with newly diagnosed DM. METHODS: A total of 78827 subjects with at least two ambulatory visits with the principal diagnosis of DM in 2001 were recruited in the DM group. The non-DM group comprised 236481, age- and sex-matched randomly sampled subjects without DM. The three-year cumulative risk of ACS was calculated using the Kaplan-Meier method. A Cox proportional hazards regression model was used to estimate the crude and adjusted hazard ratio (HR) of ACS. RESULTS: During the three-year follow-up, 946 (1.20%) subjects in the DM group and 2254 (0.95%) subjects in the non-DM group developed ACS. The crude HR of developing ACS for the DM group compared to the non-DM group was 1.333 (95% 1.236 – 1.439; p value < 0.0001), whereas the adjusted HR was 1.321 (95% 1.224 - 1.425; p value < 0.0001) after adjustment for age, sex, and dyslipidemia. CONCLUSIONS: This longitudinal population-based follow-up study shows a significantly increased risk of developing ACS after DM. © 2012 by the American College of Rheumatology. HubMed – rehab

 

Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: A double-blind, randomized, placebo-controlled trial.

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Stem Cells. 2012 Dec 24;
Min K, Song J, Kang JY, Pt JK, Ryu JS, Kang MS, Jang S, Kim SH, Oh D, Kim MK, Soo KS, Kim M

Allogeneic umbilical cord blood (UCB) has therapeutic potential for cerebral palsy (CP). Concomitant administration of recombinant human erythropoietin (rhEPO) may boost the efficacy of UCB, as it has neurotrophic effects. The objectives of this study were to assess the safety and efficacy of allogeneic UCB potentiated with rhEPO in children with CP. Children with CP, were randomly assigned to one of three parallel groups: the pUCB group, which received allogeneic UCB potentiated with rhEPO; the EPO group, which received rhEPO and placebo UCB; and the Control group, which received placebo UCB and placebo rhEPO. All participants received rehabilitation therapy. The main outcomes were changes in scores on the following measures during the six months treatment period: the Gross Motor Performance Measure (GMPM), Gross Motor Function Measure, and Bayley Scales of Infant Development-II (BSID-II) Mental and Motor scales. (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET/CT) and diffusion tensor images (DTI) were acquired at baseline and followed up to detect changes in the brain. In total, 96 subjects completed the study. Compared with the EPO (n = 33) and Control (n = 32) groups, the pUCB (n = 31) group had significantly higher scores on the GMPM and BSID-II Mental and Motor scales at six months. DTI revealed significant correlations between the GMPM increment and changes in fractional anisotropy in the pUCB group. (18) F-FDG-PET/CT showed differential activation and deactivation patterns between the three groups. The incidence of serious adverse events did not differ between groups. In conclusion, UCB treatment ameliorated motor and cognitive dysfunction in children with CP undergoing active rehabilitation, accompanied by structural and metabolic changes in the brain.
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Feasibility and reproducibility of spirometry and inductance plethysmography in healthy Brazilian preschoolers.

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Pediatr Pulmonol. 2012 Dec 31;
França DC, Camargos PA, Martins JA, Abreu MC, E Araújo GH, Parreira VF

RATIONALE: Preschoolers show peculiarities that reinforce the importance of assessing their pulmonary function. However, there are few data on the success rate and between-occasions reproducibility of pulmonary function tests in preschoolers, particularly in the Brazilian population. OBJECTIVE: To assess the success rate and between-occasions reproducibility of the variables obtained by spirometry and respiratory inductive plethysmography in healthy children aged 4-6 years. METHODS: Breathing pattern was assessed by plethysmography (tidal volume-V(T) , respiratory rate-f, inspiratory duty cycle-Ti/Ttot, mean respiratory flow-V(T) /Ti, displacement of the rib cage-RC and phase relation during the total breath-PhRTB) and spirometry (forced vital capacity-FVC, forced expiratory volume in 0.5?sec-FEV(0.5) and forced expiratory volume in first second-FEV(1) ) in 47 healthy children, aged 4-6 years. To evaluate between-occasions reproducibility, 10 children (according to the sample size calculation) were reassessed after 3 weeks. Between-occasions reproducibility was evaluated by paired t-test, considering significant P?HubMed – rehab

 


 

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