Depression Treatment: Fulminant Hepatic Failure Attributed to Ackee Fruit Ingestion in a Patient With Sickle Cell Trait.

Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait.

Filed under: Depression Treatment

Case Rep Transplant. 2012; 2012: 739238
Grunes DE, Scordi-Bello I, Suh M, Florman S, Yao J, Fiel MI, Thung SN

We report a case of fulminant liver failure resulting in emergent liver transplantation following 3 weeks of nausea, vomiting, and malaise from Jamaican Vomiting Sickness. Jamaican Vomiting Sickness is caused by ingestion of the unripe arils of the Ackee fruit, its seeds and husks. It is characterized by acute gastrointestinal illness and hypoglycemia. In severe cases, central nervous system depression can occur. In previous studies, histologic sections taken from patients with Jamaican Vomiting Sickness have shown hepatotoxicity similar to that seen in Reye syndrome and/or acetaminophen toxicity. We highlight macroscopic and microscopic changes in the liver secondary to hepatoxicity of Ackee fruit versus those caused by a previously unknown sickle cell trait. We discuss the clinical variables and the synergistic hepatotoxic effect of Ackee fruit and ischemic injury from sickled red blood cells, causing massive hepatic necrosis in this patient.
HubMed – depression


Three-dimensional visualization with large data sets: a simulation of spreading cortical depression in human brain.

Filed under: Depression Treatment

J Biomed Biotechnol. 2012; 2012: 352795
Ertürk KL, Sengül G

We developed 3D simulation software of human organs/tissues; we developed a database to store the related data, a data management system to manage the created data, and a metadata system for the management of data. This approach provides two benefits: first of all the developed system does not require to keep the patient’s/subject’s medical images on the system, providing less memory usage. Besides the system also provides 3D simulation and modification options, which will help clinicians to use necessary tools for visualization and modification operations. The developed system is tested in a case study, in which a 3D human brain model is created and simulated from 2D MRI images of a human brain, and we extended the 3D model to include the spreading cortical depression (SCD) wave front, which is an electrical phoneme that is believed to cause the migraine.
HubMed – depression


Depression and dietary intake in a cohort of HIV-positive clients in Sydney.

Filed under: Depression Treatment

Int J STD AIDS. 2012 Dec; 23(12): 882-6
Purnomo J, Jeganathan S, Begley K, Houtzager L

This cross-sectional study aimed to compare dietary intake in people living with HIV (PLHIV) experiencing symptoms of depression with those not reporting depression. The Centre for Epidemiologic Studies Depression Scale (CES-D10) was used to classify the risk of depression. Dietary nutrient intake was determined using the diet history and food frequency questionnaire. Depressed (n = 21) compared with non-depressed (n = 37) subjects had significantly lower mean intake of fibre (16.1 versus 25.4 g/day), vitamin A (801.5 versus 1524.8 mg/day), magnesium (299.8 versus 380.0 mg/day) and folate (264.8 versus 402.9 ?g/day). The proportion of subjects achieving the recommended intake of these nutrients, with the exception of folate was also found to be lower in the depressed group compared with non-depressed group. The study found that depressive symptomatology in PLHIV was associated with poorer dietary nutrient intake. A multidisciplinary model of care that includes a nutrition assessment is recommended for the management of PLHIV with depression to reduce the risk of associated nutritional problems.
HubMed – depression


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