Depression Among Women With Primary Infertility Attending an Infertility Clinic in Riyadh, Kingdom of Saudi Arabia: Rate, Severity, and Contributing Factors.

Depression among Women with Primary Infertility attending an Infertility Clinic in Riyadh, Kingdom of Saudi Arabia: Rate, Severity, and Contributing Factors.

Filed under: Depression Treatment

Int J Health Sci (Qassim). 2011 Jul; 5(2): 108-15
Al-Homaidan HT

Infertility is a severely distressing experience for many couples. Depression is considered as one of the main psychological disorders associated with infertility and it may significantly affect the life of infertile individuals, their treatment, and follow-up.The objective of the study was to determining the prevalence and predisposing factors of depressive disorders among the infertile compared to fertile women.Rate of depression was explored by this cross-sectional study carried out among women attending In-Vitro Fertilization Clinic (91 infertile women) and Well Baby Clinic (94 fertile women) at King Abdulaziz Medical City (KAMC) in Riyadh, KSA. Self administrated questionnaire including Beck Depression Inventory (BDI) was used. Mean BDI score was measured and its relation with different variables was explored, such as age, educational level, duration of infertility, pressure from family members, miscarriages and support from husband.This study showed that 49 (53.8%) of the infertile women and 35 (37.2%) of the fertile women had depression. Mean BDI score between infertile and fertile women was significantly different (p <0.001). Infertile women were found to be more severely depressed (p =0.014). Among the infertile women, those who had pressure from family members for not getting pregnant were more depressed than those with no such pressure (P=0.001).Depression is more common and severe in infertile women than fertile women. Pressure from family to get pregnant is a significant contributor to depression. Caregivers should routinely screen infertile women for depression during and after treatment for infertility and manage concomitantly. HubMed – depression treatment


Screening of plants used in Danish folk medicine to treat depression and anxiety for affinity to the serotonin transporter and inhibition of MAO-A.

Filed under: Depression Treatment

J Ethnopharmacol. 2012 Dec 20;
Jäger AK, Gauguin B, Andersen J, Adsersen A, Gudiksen L

ETHNOPHARMACOLOGICAL RELEVANCE: A number of plant species are used in Danish folk medicine for treatment of depression and anxiety. MATERIALS AND METHODS: Aqueous and ethanolic extracts of 17 plant species were tested for affinity to the serotonin transporter and for inhibition of MAO-A – both targets for antidepressive treatment. RESULTS: An ethanolic extract of aerial parts of Borago officinalis had affinity to the serotonin transporter. Eleven extracts, from 9 plants, had IC(50) values below 25?g/ml extract in the MAO-A assay. The most active extracts in the MAO-A assay were the ethanol extract of seeds of Trigonella foenum-graecum (IC(50) 4?g/ml); ethanol extract of leaves of Apium graveolens (IC(50) 5?g/ml) and the water extract of aerial parts of Calluna vulgaris (IC(50) 8?g/ml). CONCLUSIONS: Besides Borago officinalis, which toxicity profile excludes it from further development as an herbal drug, none of the plants had potential as serotonin reuptake inhibitors. Several plants had MAO-A inhibitory activity.
HubMed – depression treatment


Mindfulness significantly reduces self-reported levels of anxiety and depression: Results of a randomised controlled trial among 336 Danish women treated for stage I-III breast cancer.

Filed under: Depression Treatment

Eur J Cancer. 2012 Dec 19;
Würtzen H, Dalton SO, Elsass P, Sumbundu AD, Steding-Jensen M, Karlsen RV, Andersen KK, Flyger HL, Pedersen AE, Johansen C

INTRODUCTION: As the incidence of and survival from breast cancer continue to raise, interventions to reduce anxiety and depression before, during and after treatment are needed. Previous studies have reported positive effects of a structured 8-week group mindfulness-based stress reduction program (MBSR) among patients with cancer and other conditions. PURPOSE: To test the effect of such a programme on anxiety and depression among women with breast cancer in a population-based randomised controlled study. METHODS: A total of 336 women who had been operated on for breast cancer (stage I-III) were randomised to usual care or MBSR+usual care. Questionnaires including the Symptom Checklist-90r anxiety and depression subscales and the Center for Epidemiological Studies-Depression scale were administered before randomisation and immediately, 6 and 12 months after the intervention. RESULTS: Intention-to-treat analyses showed differences between groups in levels of anxiety (p=0.0002) and depression (SCL-90r, p<0.0001; CES-D, p=0.0367) after 12 months. Graphical comparisons of participants with higher levels of anxiety and depression at baseline showed a significantly greater decrease in the intervention group throughout follow-up and no differences among least affected participants. Medium-to-large effects were found for all outcomes in the intervention group in analyses of change scores after 12 months' follow-up. CONCLUSION: The 8-week group based MBSR intervention had clinically meaningful, statistically significant effects on depression and anxiety after 12 months' follow-up, and medium-to-large effect sizes. Our findings support the dissemination of MBSR among women with breast cancer. ( No.: NCT00990977). HubMed – depression treatment



TMS: Jeremy Roberts on The Genie Show part 1/2 – This is an interview from July of 2012 regarding TMS ( Transcranial Magnetic Stimulation ), a treatment for depression, conducted by Genie Joseph. Dr. Jeremy Roberts, based in Oahu Hawaii answers questions about TMS.


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