Autophagy: A Novel Therapeutic Target for Kidney Diseases.

Autophagy: a novel therapeutic target for kidney diseases.

Filed under: Eating Disorders

Clin Exp Nephrol. 2012 Sep 13;
Kume S, Uzu T, Maegawa H, Koya D

Autophagy meaning ‘self-eating’ in Greek, is a large-scale mechanism of intracellular degradation that seeks to maintain homeostasis in cells of all eukaryotes, from yeast to humans. Over the past several decades, autophagy research has actively proceeded both at home and abroad. As a result, studies have reported the physiological role of autophagy in different organs of mammals and of the role that impairment of its activation plays in the development of age-related diseases, abnormal glucose-lipid metabolism, and neurodegenerative disorders. Currently, new therapies targeting the regulation of activation of autophagy are anticipated, and research is continuing. In recent years, the role of autophagy in the kidneys has gradually been elucidated, and reports are indicating an association between autophagy and the development of various kidney diseases. This paper reviews the molecular mechanisms regulating autophagy and discusses new findings from autophagy research on the kidney and issues that have yet to be resolved.
HubMed – eating


Sociodemographic characteristics and food habits of organic consumers – a study from the Danish National Birth Cohort.

Filed under: Eating Disorders

Public Health Nutr. 2012 Sep 12; 1-10
Petersen SB, Rasmussen MA, Strøm M, Halldorsson TI, Olsen SF

OBJECTIVE: To develop a basis for building models that can examine the impact of organic food (OF) choices on maternal and offspring health, including identification of factors associated with OF consumption and underlying dietary patterns. DESIGN: Dietary intake was collected for the preceding month from an FFQ in mid-pregnancy and information on sociodemographic characteristics was collected from telephone interviews during pregnancy. From a question about OF consumption in the FFQ, including six food categories, an OF preference index was calculated. Latent variables that captured the variability in OF choices in relation to dietary intake were defined. SETTING: The Danish National Birth Cohort (DNBC), 1996-2002. SUBJECTS: Pregnant women from DNBC (n 60 773). RESULTS: We found that frequent OF use was highly associated with age, occupational status, urbanization, smoking and vegetarianism. By principal components analysis we identified two eating patterns, a ‘Western dietary pattern’ and a ‘Prudent dietary pattern’, that explained 14·2 % of the variability in data. Frequent OF users consumed a more ‘prudent’ diet compared with non-users and had significantly higher intakes of vegetables (+67 %), fibre (+13 %) and n-3 fatty acids (+11 %) and less saturated fat (-8 %). CONCLUSIONS: Frequent OF users seemed to have a healthier lifestyle than non-users. These findings highlight a major challenge in observational studies examining the impact of OF consumption on health due to potentially irremediable confounding factors.
HubMed – eating


Insights from the evaluation of a provincial healthy eating strategy in Nova Scotia, Canada.

Filed under: Eating Disorders

Public Health Nutr. 2012 Sep 12; 1-9
Sim SM, Kirk SF

OBJECTIVE: Healthy Eating Nova Scotia represents the first provincial comprehensive healthy eating strategy in Canada and a strategy that is framed within a population-health model. Five years after strategy launch, our objective was to evaluate Healthy Eating Nova Scotia to determine perceptions of strategy implementation and strategy outputs. The focus of the current paper is on the findings of this evaluation. DESIGN: We conducted an evaluation of the strategy through three activities that included a document review, survey of key stakeholders and in-depth interviews with key strategy informants. The findings from each of the activities were integrated to determine what has worked well with strategy implementation, what could be improved and what outputs have resulted. SETTING: The evaluation was conducted in the Canadian province of Nova Scotia. Participants Participants for this evaluation included survey respondents (n 120) and key informants (n 16). A total of 156 documents were also reviewed. RESULTS: Significant investments have been made towards inter-sectoral partnerships and resourcing that has provided the necessary leadership and momentum for the strategy. Policy development has been leveraged through the strategy primarily in the health and education sectors and is perceived as a visible success. Clarity of human resource roles and funding within the context of a provincial strategy may be beneficial for continued strategy implementation, as is expansion of policy development. CONCLUSIONS: Known to be the first evaluation of its kind, these findings and related considerations will be of interest to policy makers developing and implementing similar strategies in their own jurisdictions.
HubMed – eating


The primary care diagnosis and management of bulimia nervosa and its relevance in the UK Armed Forces.

Filed under: Eating Disorders

J R Nav Med Serv. 2012; 98(2): 6-12
Ingram SJ, Coetzee RH

Bulimia Nervosa is an eating disorder that is frequently seen in the UK Armed Forces population. In this article the diagnosis, management and clinical considerations of managing this condition in Primary Care in the UKArmed Forces are considered. The occupational and operational considerations for the military environment are also discussed.
HubMed – eating



Recovery from Eating Disorders – Making choices are very scarey when you think that everything you do will be embedded forever in the annuls of history. The truth is, you can change your mind about ANYTHING and the earth WILL keep spinning. The sun will come out in the morning, and life will go on. The trick is learning to discern between poor choices, good choices, and commitments to improve, or do better. THOSE are the commitments we want to keep, but, the choice to keep them is forever in our power.


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