Update in Pediatric Anaphylaxis: A Systematic Review.
Update in Pediatric Anaphylaxis: A Systematic Review.
Filed under: Drug and Alcohol Rehabilitation
Clin Pediatr (Phila). 2013 Feb 7;
Chipps BE
Anaphylaxis is common in children and has many differences across age groups. A systematic review of the literature from the past 5 years was conducted with the goal of updating the pediatrician. Food is the most common trigger in children, but insect venom and drugs are other typical causes. Clinical diagnostic criteria include dermatological, respiratory, cardiovascular, and gastrointestinal manifestations. A biphasic reaction is seen in some, with recurrence usually within 8 hours of the initial episode. Epinephrine is the drug of choice for acute reactions and the only medication shown to be lifesaving when administered promptly, but it is underutilized. Patients should have ready access to ?2 doses of an epinephrine autoinjector, with thorough training regarding correct use of a given device and an emergency action plan. Management of anaphylaxis in schools presents distinct challenges. Pediatricians are in a unique position to assess and treat these patients chronically.
HubMed – drug
Erlotinib Plus Parenteral Nutrition: An Opportunity to Get Through the Hardest Days of Advanced Non-Small Cell Lung Cancer With Cancer Anorexia-Cachexia Syndrome.
Filed under: Drug and Alcohol Rehabilitation
Am J Hosp Palliat Care. 2013 Feb 6;
Zang YS, Fang Z, Li B
This case study details the poor performance status of a patient with non-small cell lung cancer and cancer anorexia-cachexia syndrome got through the hardest days of high tumor burden and malnutrition, by using a combined therapy of lung cancer-targeted therapy drug and parenteral nutrition. The related literatures were reviewed.
HubMed – drug
Proton donor acidity controls selectivity in nonaromatic nitrogen heterocycle synthesis.
Filed under: Drug and Alcohol Rehabilitation
Science. 2013 Feb 8; 339(6120): 678-82
Duttwyler S, Chen S, Takase MK, Wiberg KB, Bergman RG, Ellman JA
Piperidines are prevalent in natural products and pharmaceutical agents and are important synthetic targets for drug discovery and development. We report on a methodology that provides highly substituted piperidine derivatives with regiochemistry selectively tunable by varying the strength of acid used in the reaction. Readily available starting materials are first converted to dihydropyridines via a cascade reaction initiated by rhodium-catalyzed carbon-hydrogen bond activation. Subsequent divergent regio- and diastereoselective protonation of the dihydropyridines under either kinetic or thermodynamic control provides two distinct iminium ion intermediates that then undergo highly diastereoselective nucleophilic additions. X-ray structural characterization of both the kinetically and thermodynamically favored iminium ions along with density functional theory calculations provide a theoretical underpinning for the high selectivities achieved for the reaction sequences.
HubMed – drug
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