The Impact of Brief Psychotherapy Centred on Parenthood on the Anxio-Depressive Symptoms of Mothers During the Perinatal Period.

The impact of brief psychotherapy centred on parenthood on the anxio-depressive symptoms of mothers during the perinatal period.

Swiss Med Wkly. 2013; 143: 0
Moayedoddin A, Moser DA, Nanzer N

Depression and anxiety are major causes of distress amongst parents during the perinatal period. Their pervasive effects on the parents’ self-confidence, on the parent-infant relationship and on the child’s development have been well documented. The aims of the present study were to describe the psychological characteristics of mothers consulting during the perinatal period and to assess the effect of brief Psychotherapy Centred on Parenthood (PCP) on the mothers’ depressive and anxiety symptoms. The evolution of the mother-infant relationship is also documented. PCP is a brief mother-infant psychotherapy which focuses on the mother-infant relationship as well as the mother’s mental representations in order to reduce her psychological conflicts.Thirty-four mothers consulting an infant-parent outpatient clinic were assessed with respect to depression, anxiety, global functioning, severity of symptoms and the quality of their adaptation to the infant (T1). They were offered a brief PCP with an average of seven sessions. Outcome measures were collected after the end of the therapy (T2).Overall, 28 of 34 mothers completed the therapy (83%), and 23 participated in the post-therapy evaluation. Paired samples t-tests showed that completers of PCP displayed significant improvement in post-treatment measures of depression (EPDS: t = 5.13; p <0.001), anxiety (STAI-State: t = 3.06; p = 0.006), clinical impression (CGI: n = 21; t = 4.50; p <0.001), and global functioning (GAF: t = -5.05; p <0.001). The quality of adaptation in the infant-parent relationship showed a tendency to improve (PIRGAS: t = -1.98; p = 0.062).These preliminary results suggested that providing PCP to this sample of consulting mothers is feasible and accompanied by high rate of clinical and functional improvement. HubMed – depression


Effect of Intraoperative Dexmedetomidine on Postoperative Recovery Profile of Children Undergoing Surgery for Spinal Dysraphism.

J Neurosurg Anesthesiol. 2013 Mar 19;
Gupta N, Rath GP, Prabhakar H, Dash HH

BACKGROUND:: Smooth recovery from anesthesia is desirable in children undergoing surgery for spinal dysraphism who are nursed in prone position during the postoperative period. Dexmedetomidine may be beneficial in these children owing to its sedative, anxiolytic, and opioid-sparing properties with minimal respiratory depression. METHODS:: Thirty-six children with spinal dysraphism at lumbosacral area, aged 8 to 12 years, undergoing corrective surgery were randomized to receive either dexmedetomidine or volume-matched saline (placebo) after positioned prone until beginning of skin closure. Inspired concentration of sevoflurane was changed to keep the bispectral index score between 45 and 55. Perioperative hemodynamics, intraoperative fentanyl and sevoflurane consumption, and postoperative recovery profile and fentanyl consumption was observed by blinded observers. Postoperative pain, emergence agitation (EA), and discharge readiness from postanesthesia care unit was evaluated using the modified objective pain score, agitation Cole score, and modified Aldrete score, respectively. Fentanyl 0.5-1 µg/kg was administered for pain (objective pain score ?4) or severe EA (agitation Cole score ?4) lasting for >5 minutes. RESULTS:: The 2 groups did not differ significantly with respect to demographics, duration of anesthesia, emergence, and extubation times. The intraoperative consumption of sevoflurane and fentanyl was significantly less in dexmedetomidine group (0.2±0.1 vs. 0.3±0.1 mL/min, P<0.0001 and 2.3±0.5 vs. 3.1±0.6 ?g/kg, P=0.0001, respectively), along with a lower mean heart rate (P<0.001). The mean systolic blood pressure (P=0.98) and incidence of bradycardia and hypotension was comparable in between the 2 groups. Postoperatively, the children in dexmedetomidine group had significantly lower pain scores (P<0.0001), agitation scores (P<0.0001), and time to achieve full modified Aldrete score [0 (0 to 10) vs. 10 (0 to 20) min, P=0.001]. The postoperative consumption of fentanyl was significantly less in dexmedetomidine group [0 (0 to 1.04) vs. 0.88 (0 to 3) µg/kg, P=0.003], along with a longer time of first analgesic requirement [600 (5 to 2100) vs. 5 (5 to 185) min, P=0.0001]. The mean heart rate and systolic blood pressure were higher in placebo group (P<0.001), whereas no difference was observed in respiratory rate (P=0.73) and arterial oxygen saturation (P=0.36). The number of patients with postoperative nausea and vomiting was significantly lower in dexmedetomidine group [2 (11.1%) vs. 9 (50%), P=0.03]. CONCLUSIONS:: Intraoperative use of dexmedetomidine in children undergoing spinal surgery results in a favorable recovery profile with reduced postoperative pain and EA, without adverse perioperative hemodynamic effects. HubMed – depression


A Double-blind, Placebo-Controlled Study of the Impact of Galantamine on Anterograde Memory Impairment During Electroconvulsive Therapy.

J ECT. 2013 Mar 20;
Matthews JD, Siefert CJ, Blais MA, Park LT, Siefert CJ, Welch CA, Dubois CM, van Nieuwenhuizen AO, Rooney KO, Seabrook RC, Durham LE, Adams HC, Fava M

BACKGROUND: Electroconvulsive therapy (ECT) continues to be an effective treatment option for patients who fail to respond to pharmacological interventions, are unable to tolerate medications, and show a suboptimal response to behavioral and psychotherapeutic treatments. However, risks for cognitive impairment may contribute to some patients’ refusal of ECT. METHODS: The present study examined galantamine as a pharmacological intervention to reduce cognitive adverse effects from ECT. Thirty-nine inpatients diagnosed with major depressive disorder; bipolar disorder, depressed type; or schizoaffective disorder, depressed type and admitted for ECT were randomized to galantamine or placebo. Study drugs were initiated 24 to 48 hours before starting ECT and continued throughout the course of ECT. A neuropsychological test battery was administered at baseline and 24 to 48 hours after completing a course of ECT treatments. Depression severity was monitored using the 17-item Hamilton Rating Scale for Depression and Clinical Global Impression Scale at baseline, weekly, and end point. Self-rated adverse effects were monitored weekly. RESULTS: Thirty participants (12 patients in the galantamine group, 18 patients in the placebo group) had both pretreatment and posttreatment neuropsychological ratings. Those in the galantamine group scored significantly higher at discharge for delayed memory (t28 = 2.44, P < 0.05). Hierarchical regressions examined if treatment condition predicted changes in delayed memory scores from baseline to discharge. Inclusion of the treatment condition in the final model made a significant incremental improvement in prediction (?R = 0.12, F1,27 change = 4.65, P < 0.05; ? = 0.37, t = 2.16, P < 0.05). Galantamine was well tolerated with no clinically significant bradycardia or prolonged paralysis when administered with ECT. CONCLUSIONS: Galantamine may be protective against impairment in retention of new learning. Galantamine exhibited minimal adverse effects and was safe when administered during ECT. The present findings require replication by future researchers using larger samples before broad conclusions can be drawn. HubMed – depression


Maintenance Therapy With Electroconvulsive Therapy in a Patient With a Codiagnosis of Bipolar Disorder and Obsessive-Compulsive Disorder.

J ECT. 2013 Mar 20;
Bülbül F, Copoglu US, Alpak G, Unal A, Tastan MF, Savas HA

Obsessive-compulsive disorder (OCD) is defined as the most commonly seen anxiety disorder accompanying the bipolar disorder, and this concomitance causes the difficulties in the therapy. Although electroconvulsive therapy (ECT) is efficient in both manic and depressive episodes of the bipolar disorder, it is considered as a therapeutic option in cases of OCD with depression comorbidity. In this article, we aimed to present a case in which depressive episode of bipolar disorder and OCD comorbidity were present; both depressive and OCD symptoms were resolved using ECT. Symptoms of both diseases recurred after the discontinuation of ECT, and well-being sustained with maintenance ECT. HubMed – depression