The Impact of Ankylosing Spondylitis on Female Sexual Functions.

The impact of ankylosing spondylitis on female sexual functions.

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Int J Impot Res. 2013 Jan 10;
Sariyildiz MA, Batmaz I, Inanir A, Dilek B, Bozkurt M, Bez Y, Karakoç M, Cevik R

The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables, psychological status and the quality of life on the female patients‘ sexual function measured according to the Female Sexual Function Index (FSFI). Thirty-seven sexually active female AS patients and 33 healthy controls were enroled in this study. Their demographic data were evaluated and the generalised pain in patients with AS was assessed according to the visual analogue scale (0-100?mm). Laboratory tests were conducted in order to measure the C-reactive protein (CRP) and erythrocyte sedimentation rates (ESR) of the patients. In comparison to the healthy control group, patients with AS had significantly lower scores in each of the five domains of the FSFI except for the pain domain (P<0.05). The disease activity, functional status, quality of life, radiological score and CRP levels were negatively correlated with the FSFI (P<0.05). No significant correlation was observed with the disease duration, smoking status, depression, anxiety, pain and ESR when the total scores and the scores from the domains of the FSFI were compared. The sexual function is impaired in female patients with AS. This impairment in the sexual function is especially related to the functional status and disease activity among the clinical and laboratory parameters.International Journal of Impotence Research advance online publication, 10 January 2013; doi:10.1038/ijir.2012.42. HubMed – rehab


Physical Exercise Induces Excess Hsp72 Expression and Delays the Development of Hyperalgesia and Allodynia in Painful Diabetic Neuropathy Rats.

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Anesth Analg. 2013 Jan 9;
Chen YW, Hsieh PL, Chen YC, Hung CH, Cheng JT

BACKGROUND:The underlying mechanism of exercise on the development of diabetes-associated neuropathic pain is not well understood. We investigated in rats whether exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor (TNF)-?, and interleukin (IL)-6 expression in streptozotocin (STZ)-induced diabetes.METHODS:Male Wistar rats were divided into 4 groups: normal sedentary rats, normal rats with exercise, sedentary STZ-diabetic (SS) rats, and STZ-diabetic rats with exercise. Diabetes was induced with STZ (65 mg/kg IV). The trained rats ran daily on a treadmill 30 to 60 min/d with an intensity of 20 to 25 m/min. We monitored thermal withdrawal latency and mechanical withdrawal threshold as well as Hsp72, TNF-?, and IL-6 expression in the spinal cord and peripheral nerves.RESULTS:Two weeks after STZ injection, sedentary rats exhibited a marked and sustained hypersensitivity to von Frey tactile and heat stimuli. In contrast, diabetic rats undergoing exercise demonstrated delayed progress of tactile and thermal hypersensitivity. Exercise significantly suppressed diabetes-induced blood glucose levels and body weight loss, although they were not restored to control levels. Compared with normal sedentary rats, SS rats displayed significantly higher TNF-? and IL-6 levels in the spinal cord and peripheral nerves. The STZ-diabetic rats with exercise group showed greater Hsp72 expression and similar TNF-? or IL-6 level compared with the SS group in the spinal cord and peripheral nerves on day 14 after STZ treatment.CONCLUSIONS:These results suggest that progressive exercise training markedly decreases diabetes-associated neuropathic pain, including thermal hyperalgesia and mechanical allodynia. In rats, this protective effect is related to the increase of Hsp72, but not TNF-? and IL-6, expression in the spinal cord and peripheral nerves of STZ-induced diabetes.
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‘Rehab’ helps errant researchers return to the lab.

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Nature. 2013 Jan 10; 493(7431): 147
Cressey D

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