transcription factor

Repressive Epigenetic Changes at the Mglu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice.

Repressive Epigenetic Changes at the Mglu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice.

Mol Pharmacol. 2013 Mar 18;
Kurita M, Moreno JL, Holloway T, Kozlenkov A, Mocci G, Garcia-Bea A, Hanks JB, Neve R, Nestler EJ, Russo SJ,… Continue reading

CREB Is Necessary for Synaptic Maintenance and Learning-Induced Changes of the Ampa Receptor GluA1 Subunit.

CREB is necessary for synaptic maintenance and learning-induced changes of the ampa receptor GluA1 subunit.

Hippocampus. 2013 Mar 18;
Middei S, Houeland G, Cavallucci V, Ammassari-Teule M, D’Amelio M, Marie H

The transcription factor cAMP response element binding protein… Continue reading

Repeated Cocaine Exposure Increases Fast-Spiking Interneuron Excitability in the Rat Medial Prefrontal Cortex.

Repeated Cocaine Exposure Increases Fast-Spiking Interneuron Excitability in the Rat Medial Prefrontal Cortex.

J Neurophysiol. 2013 Mar 13;
Campanac E, Hoffman DA

The medial prefrontal cortex plays a key role in cocaine addiction. However, how chronic cocaine exposure affects… Continue reading

Propagation of Adult SSCs: From Mouse to Human.

Propagation of Adult SSCs: From Mouse to Human.

Biomed Res Int. 2013; 2013: 384734
Martin LA, Seandel M

Adult spermatogonial stem cells (SSCs) represent a distinctive source of stem cells in mammals for several reasons. First, by giving rise… Continue reading

The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells.

The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells.

J Immunol. 2013 Mar 4;
Wang Q, Franks HA, Lax SJ, El Refaee M, Malecka A, Shah S, Spendlove I, Gough MJ, Seedhouse C, Madhusudan S,… Continue reading

Kinetic Modeling-Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network.

Kinetic Modeling-Based Detection of Genetic Signatures that Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network.

Cancer Res. 2013 Feb 27;
Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Putzer BM

Drug resistance is a major cause of… Continue reading

Efficacy of Quetiapine in Patients With Bipolar I and II Depression: A Multicenter, Prospective, Open-Label, Observational Study.

Efficacy of quetiapine in patients with bipolar I and II depression: a multicenter, prospective, open-label, observational study.

Neuropsychiatr Dis Treat. 2013; 9: 197-204
Jeong JH, Bahk WM, Woo YS, Seo HJ, Hong SC, Jon DI, Min KJ, Yoon BH… Continue reading

Transcriptional Mechanisms of Drug Addiction.

Transcriptional mechanisms of drug addiction.

Clin Psychopharmacol Neurosci. 2012 Dec; 10(3): 136-43
Nestler EJ

Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription… Continue reading

Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms With ?FosB as a Key Mediator.

Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ?FosB as a Key Mediator.

J Neurosci. 2013 Feb 20; 33(8): 3434-3442
Pitchers KK, Vialou V, Nestler EJ, Laviolette SR, Lehman MN, Coolen LM

Drugs of abuse induce… Continue reading