therapeutic target

The Effects of Smoking on Steroid Metabolism and Fetal Programming.

The effects of smoking on steroid metabolism and fetal programming.

J Steroid Biochem Mol Biol. 2013 May 14;
Dušková M, Hruškovi?ová H, Sim?nková K, Stárka L, Pa?ízek A

Tobacco addiction is a serious psychosocial and health problem. A pregnant… Continue reading

Pearls and Pitfalls in Experimental Models of Spreading Depression.

Pearls and pitfalls in experimental models of spreading depression.

Cephalalgia. 2013 Jun; 33(8): 604-13
Ayata C

Spreading depression (SD) is the electrophysiological substrate of migraine aura and a potential trigger for headache. Since its discovery by Leão in 1944,… Continue reading

Producing the “Problem” of Addiction in Drug Treatment.

Producing the “Problem” of Addiction in Drug Treatment.

Qual Health Res. 2013 May 3;
Moore D, Fraser S

In this article, we argue that the “problem” of addiction emerges as an effect of treatment policy and practice as well… Continue reading

Impact of Repeated Intravenous Cocaine Administration on Incentive Motivation Depends on Mode of Drug Delivery.

Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery.

Addict Biol. 2013 May 3;
Leblanc KH, Maidment NT, Ostlund SB

The incentive sensitization theory of addiction posits that repeated exposure to drugs of… Continue reading

Antecedents and Consequences of Drug Abuse in Rats Selectively Bred for High and Low Response to Novelty.

Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty.

Neuropharmacology. 2013 Apr 29;
Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H

Human genetic and epidemiological studies provide evidence that… Continue reading

Antidepressant Effect of Aminophylline After Ethanol Exposure.

Antidepressant effect of aminophylline after ethanol exposure.

Sci Pharm. 2013 Mar; 81(1): 211-22
Escudeiro SS, Soares PM, Almeida AB, de Freitas Guimarães Lobato R, de Araujo DP, Macedo DS, Sousa FC, Patrocínio MC, Vasconcelos SM

This work investigated the… Continue reading

The Role of Galanin System in Modulating Depression, Anxiety, and Addiction-Like Behaviors After Chronic Restraint Stress.

The role of galanin system in modulating depression, anxiety, and addiction-like behaviors after chronic restraint stress.

Neuroscience. 2013 Apr 29;
Zhao X, Seese RR, Yun K, Peng T, Wang Z

There is high comorbidity between stress-related psychiatric disorders and… Continue reading

Application of Liposomes in Drug Development – Focus on Gastroenterological Targets.

Application of liposomes in drug development – focus on gastroenterological targets.

Int J Nanomedicine. 2013; 8: 1325-34
Zhang JX, Wang K, Mao ZF, Fan X, Jiang DL, Chen M, Cui L, Sun K, Dang SC

Over the past decade,… Continue reading

Noninvasive Visualization of MicroRNA-16 in the Chemoresistance of Gastric Cancer Using a Dual Reporter Gene Imaging System.

Noninvasive Visualization of MicroRNA-16 in the Chemoresistance of Gastric Cancer Using a Dual Reporter Gene Imaging System.

PLoS One. 2013; 8(4): e61792
Wang F, Song X, Li X, Xin J, Wang S, Yang W, Wang J, Wu K, Chen… Continue reading

A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs.

A Model of Postsurgical Advanced Metastatic Breast Cancer More Accurately Replicates the Clinical Efficacy of Antiangiogenic Drugs.

Cancer Res. 2013 Apr 22;
Guerin E, Man S, Xu P, Kerbel RS

The failure rate of randomized phase III oncology clinical… Continue reading