Lifetime Recovery Part 1
Lifetime Recovery Part 1 – Successful Drug Treatment Since 1963 Lifetime Recovery and our parent, Alcoholic Rehabilitation Center, have provided focused, meaningful, treatment for chemical dependency to the people of Bexar County since 1963. Our residential campus is San… Continue reading
Role of Reactive Oxygen Species in the Synergistic Cytotoxicity of Safingol-Based Combination Regimens With Conventional Chemotherapeutics.
Role of reactive oxygen species in the synergistic cytotoxicity of safingol-based combination regimens with conventional chemotherapeutics.
Filed under: Drug and Alcohol Rehabilitation
Oncol Lett. 2011 Sep 1; 2(5): 905-910
Ling LU, Tan KB, Chiu GN
Exploiting the sensitivity of cancer cells to reactive oxygen species (ROS) has been suggested as a strategy for the selective elimination of cancer cells. In this study, the ROS-generating sphingolipid safingol was combined with various conventional chemotherapeutics, and the potential synergism of the safingol-based combination regimen was assessed using a panel of cancer cell lines. The IC(50) values of safingol using as a single agent were 1.4-6.3 µM, which are concentrations that are clinically achievable. While synergism was dependent on the drug molar ratios, a 4:1 molar ratio of safingol to conventional chemotherapeutics exhibited a moderate to strong synergism in MDA-MB-231, JIMT-1, SKOV-3, U937 and KB cells, with combination indices ranging from 0.07 to 0.77. Furthermore, the addition of safingol may reduce the concentrations of conventional chemotherapeutics required to achieve 90% cell-kill by 1 to >3 log-folds. A significant… Continue reading
Rehab Centers in Bc: How to Choose the Best Drug and Alcohol Rehab Center
Alcohol or drugs are dangerous material or matter of abuses because of their devastating effects on the human body, especially the liver gets damaged by alcohol and drug affects all parts of the body. Alcoholics cannot get rid from the… Continue reading
Drug and Alcohol Rehabilitation: Exclusive Florida Beach Town Furious After Vacant Mansion Turned Into Drug and Alcohol Rehabilitation Clinic – Daily Mail
Exclusive Florida beach town furious after vacant mansion turned into drug and alcohol rehabilitation clinic – Daily Mail
Filed under: Drug and Alcohol Rehabilitation
A lavish mansion on an exclusive beachfront has been turned into a drug rehabilitation clinic angering… Continue reading