potassium channel

Do Optimal Antihypertensive Drug Regimens Allow Blood Pressure Normalization in All Patients With Resistant Hypertension?

Do Optimal Antihypertensive Drug Regimens Allow Blood Pressure Normalization in All Patients With Resistant Hypertension?

Hypertension. 2013 Aug 5;
Waeber B, Feihl F

HubMed – drug

Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined… Continue reading

Activation of CRH Receptor Type 1 Expressed on Glutamatergic Neurons Increases Excitability of CA1 Pyramidal Neurons by the Modulation of Voltage-Gated Ion Channels.

Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels.

Front Cell Neurosci. 2013; 7: 91
Kratzer S, Mattusch C, Metzger MW, Dedic N, Noll-Hussong M,… Continue reading

Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation.

Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation.

PLoS One. 2013; 8(7): e69551
Tricarico D, Mele A, Calzolaro S, Cannone G, Camerino GM, Dinardo MM,… Continue reading

Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania Somnifera, Warbugia Ugandensis, Prunus Africana and Plectrunthus Barbatus.

Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus.

PLoS One. 2013; 8(6): e65619
Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC

Withania somnifera, Warbugia… Continue reading

Replication of Genome-Wide Association Studies (GWAS) Loci for Sleep in the British G1219 Cohort.

Replication of Genome-Wide association studies (GWAS) loci for sleep in the British G1219 cohort.

Am J Med Genet B Neuropsychiatr Genet. 2013 Jul; 162(5): 431-8
Parsons MJ, Lester KJ, Barclay NL, Nolan PM, Eley TC, Gregory AM

Sleep is… Continue reading

ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Anti-Epileptic Properties in Mice.

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays anti-epileptic properties in mice.

ACS Chem Neurosci. 2013 Jun 3;
Kaufmann KW, Romaine IM, Days E, Pascual C, Malik A, Yang L, Zou B, Du… Continue reading

Anti-Addiction Drug Ibogaine Inhibits Voltage-Gated Ionic Currents: A Study to Assess the Drug’s Cardiac Ion Channel Profile.

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug’s cardiac ion channel profile.

Toxicol Appl Pharmacol. 2013 May 22;
Koenig X, Kovar M, Rubi L, Mike AK, Lukacs P, Gawali VS, Todt H, Hilber K,… Continue reading

Major Channels Involved in Neuropsychiatric Disorders and Therapeutic Perspectives.

Major channels involved in neuropsychiatric disorders and therapeutic perspectives.

Front Genet. 2013; 4: 76
Imbrici P, Camerino DC, Tricarico D

Voltage-gated ion channels are important mediators of physiological functions in the central nervous system. The cyclic activation of these… Continue reading

Dynamic Subunit Stoichiometry Confers a Progressive Continuum of Pharmacological Sensitivity by KCNQ Potassium Channels.

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.

Proc Natl Acad Sci U S A. 2013 May 6;
Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus… Continue reading

Genetic Mediators of Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia.

Genetic Mediators of Neurocognitive Outcomes in Survivors of Childhood Acute Lymphoblastic Leukemia.

J Clin Oncol. 2013 May 6;
Krull KR, Bhojwani D, Conklin HM, Pei D, Cheng C, Reddick WE, Sandlund JT, Pui CH

PURPOSESurvivors of childhood acute lymphoblastic… Continue reading