Multiple Myeloma

Physical Activity and Depression Symptom Profiles in Young Men and Women With Major Depression.

Published April 12, 2013

Physical Activity and Depression Symptom Profiles in Young Men and Women With Major Depression.

Psychosom Med. 2013 Apr 10;
McKercher C, Patton GC, Schmidt MD, Venn AJ, Dwyer T, Sanderson K

ObjectiveThis study explored whether young adults with major… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

Published February 26, 2013

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

PLoS Curr. 2013; 5:
Chen JY, Wang E, Galvan L, Huynh M, Joshi P, Cepeda C, Levine MS

This… Continue reading →

Serum Concentrations and Hypoglycemic Effect of Gliclazide:crosspovidone Solid Dispersion on Streptozotocin Induced Diabetic Rats.

Published February 22, 2013

Serum concentrations and hypoglycemic effect of gliclazide:crosspovidone solid dispersion on streptozotocin induced diabetic rats.

Drug Res (Stuttg). 2013 Feb; 63(2): 94-7
Adibkia K, Babaei H, Asnaashari S, Andalib S, Khorrami A, Ghavimi H, Jadidinia V, Hajiloo H, Barzegar-Jalali M… Continue reading →

Drug and Alcohol Rehabilitation: Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-Child-Transmission of HIV in Tanzania.

Published February 14, 2013

Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-Child-Transmission of HIV in Tanzania.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2013; 8(2): e55633
Ziske J, Kunz A, Sewangi J, Lau I, Dugange… Continue reading →

Drug and Alcohol Rehabilitation: Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

Published February 7, 2013

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

Filed under: Drug and Alcohol Rehabilitation

Front Pharmacol. 2013; 4: 5
Davidson D, Amrein L, Panasci L, Aloyz R

Many current chemotherapies function by damaging genomic DNA in rapidly… Continue reading →

[Developmental Dysphasia: Assessment of the Drug Treatment Efficacy].

Published January 19, 2013

[Developmental dysphasia: assessment of the drug treatment efficacy].

Filed under: Drug and Alcohol Rehabilitation

Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(7 Pt 2): 90-5

To assess the efficacy of treatment with encephabol, we examined 40 children, aged… Continue reading →

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats.

Published December 28, 2012

Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats.

Filed under: Depression Treatment

Korean J Physiol Pharmacol. 2012 Dec; 16(6): 379-86
Lee B, Sur B, Yeom… Continue reading →

Paramount Prognostic Factors That Guide Therapeutic Strategies in Diffuse Large B-Cell Lymphoma.

Published December 13, 2012

Paramount prognostic factors that guide therapeutic strategies in diffuse large B-cell lymphoma.

Filed under: Drug and Alcohol Rehabilitation

Hematology Am Soc Hematol Educ Program. 2012; 2012: 402-9
Sehn LH

Outcome in diffuse large B-cell lymphoma (DLBCL) has improved over… Continue reading →

Treatment of Experimental Ulcerative Colitis.

Published November 1, 2012

Treatment of experimental ulcerative colitis.

Filed under: Drug and Alcohol Rehabilitation

Bull Exp Biol Med. 2012 Oct; 153(6): 889-92
Lazebnik LB, Lychkova AE, Knyazev OV

The effects of infliximab, an anticytokine drug, on the course of inflammatory process was… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

Serum Concentrations and Hypoglycemic Effect of Gliclazide:crosspovidone Solid Dispersion on Streptozotocin Induced Diabetic Rats.

Drug and Alcohol Rehabilitation: Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-Child-Transmission of HIV in Tanzania.

Drug and Alcohol Rehabilitation: Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

[Developmental Dysphasia: Assessment of the Drug Treatment Efficacy].

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats.

Paramount Prognostic Factors That Guide Therapeutic Strategies in Diffuse Large B-Cell Lymphoma.

Treatment of Experimental Ulcerative Colitis.

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