Mouse Model

Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.

Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.

PLoS One. 2013; 8(2): e57140
Kandeel M, Kitade Y

RNA interference (RNAi) is a highly specialized process of protein-siRNA interaction… Continue reading →

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.

PLoS One. 2013; 8(2): e57445
Zhang B, McDaniel SS, Rensing NR, Wong M

Epilepsy is a common neurological disorder and cause of significant morbidity… Continue reading →

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

PLoS Curr. 2013; 5:
Chen JY, Wang E, Galvan L, Huynh M, Joshi P, Cepeda C, Levine MS

This… Continue reading →

Drug and Alcohol Rehabilitation: Protein-Chemical Interaction Prediction via Kernelized Sparse Learning Svm.

Protein-chemical interaction prediction via kernelized sparse learning svm.

Filed under: Drug and Alcohol Rehabilitation

Pac Symp Biocomput. 2013; 41-52
Shi Y, Zhang X, Liao X, Lin G, Schuurmans D

Given the difficulty of experimental determination of drug-protein interactions, there… Continue reading →

Translational Regulation of RPA2 via Internal Ribosomal Entry Site and by eIF3a.

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a.

Filed under: Drug and Alcohol Rehabilitation

Carcinogenesis. 2013 Feb 7;
Yin JY, Dong ZZ, Liu RY, Chen J, Liu ZQ, Zhang JT

RPA2 is a subunit of… Continue reading →

Dendritic Cells Loaded With FK506 Kill T Cells in an Antigen-Specific Manner and Prevent Autoimmunity in Vivo.

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.

Filed under: Drug and Alcohol Rehabilitation

elife. 2013; 2: e00105
Orange DE, Blachere NE, Fak J, Parveen S, Frank MO, Herre M,… Continue reading →

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides.

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides.

Filed under: Drug and Alcohol Rehabilitation

Drug Metab Dispos. 2013 Feb 5;
Inoue NR, Hall A, Lai WG, Williams ET

Carboxylesterases hydrolyze esters, amides, and thioesters to produce carboxylic acids and… Continue reading →

Addiction Rehab: [Rapid Release Fentanyl Administration Forms : Comments of the Working Group on Tumor Pain of the German Pain Society.]

[Rapid release fentanyl administration forms : Comments of the Working Group on Tumor Pain of the German Pain Society.]

Filed under: Addiction Rehab

Schmerz. 2013 Feb 3;
Wirz S, Wiese CH, Zimmermann M, Junker U, Heuser-Grannemann E, Schenk M… Continue reading →

Addiction Rehab: Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning.

Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning.

Filed under: Addiction Rehab

Neuron. 2013 Jan 23; 77(2): 335-45
Whitaker LR, Degoulet M, Morikawa H

Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social… Continue reading →

Depression Treatment: Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis.

Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.

Filed under: Depression Treatment

PLoS One. 2013; 8(1): e54666
Nisticò R, Mango D, Mandolesi G, Piccinin S, Berretta N, Pignatelli M, Feligioni M, Musella A, Gentile A, Mori F, Bernardi… Continue reading →