Mouse Model

Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.

Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.

PLoS One. 2013; 8(2): e57140
Kandeel M, Kitade Y

RNA interference (RNAi) is a highly specialized process of protein-siRNA interaction… Continue reading

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.

PLoS One. 2013; 8(2): e57445
Zhang B, McDaniel SS, Rensing NR, Wong M

Epilepsy is a common neurological disorder and cause of significant morbidity… Continue reading

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease.

PLoS Curr. 2013; 5:
Chen JY, Wang E, Galvan L, Huynh M, Joshi P, Cepeda C, Levine MS

This… Continue reading

Drug and Alcohol Rehabilitation: Protein-Chemical Interaction Prediction via Kernelized Sparse Learning Svm.

Protein-chemical interaction prediction via kernelized sparse learning svm.

Filed under: Drug and Alcohol Rehabilitation

Pac Symp Biocomput. 2013; 41-52
Shi Y, Zhang X, Liao X, Lin G, Schuurmans D

Given the difficulty of experimental determination of drug-protein interactions, there… Continue reading

Translational Regulation of RPA2 via Internal Ribosomal Entry Site and by eIF3a.

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a.

Filed under: Drug and Alcohol Rehabilitation

Carcinogenesis. 2013 Feb 7;
Yin JY, Dong ZZ, Liu RY, Chen J, Liu ZQ, Zhang JT

RPA2 is a subunit of… Continue reading

Dendritic Cells Loaded With FK506 Kill T Cells in an Antigen-Specific Manner and Prevent Autoimmunity in Vivo.

Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo.

Filed under: Drug and Alcohol Rehabilitation

elife. 2013; 2: e00105
Orange DE, Blachere NE, Fak J, Parveen S, Frank MO, Herre M,… Continue reading

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides.

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides.

Filed under: Drug and Alcohol Rehabilitation

Drug Metab Dispos. 2013 Feb 5;
Inoue NR, Hall A, Lai WG, Williams ET

Carboxylesterases hydrolyze esters, amides, and thioesters to produce carboxylic acids and… Continue reading

Addiction Rehab: [Rapid Release Fentanyl Administration Forms : Comments of the Working Group on Tumor Pain of the German Pain Society.]

[Rapid release fentanyl administration forms : Comments of the Working Group on Tumor Pain of the German Pain Society.]

Filed under: Addiction Rehab

Schmerz. 2013 Feb 3;
Wirz S, Wiese CH, Zimmermann M, Junker U, Heuser-Grannemann E, Schenk M… Continue reading

Addiction Rehab: Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning.

Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning.

Filed under: Addiction Rehab

Neuron. 2013 Jan 23; 77(2): 335-45
Whitaker LR, Degoulet M, Morikawa H

Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social… Continue reading

Depression Treatment: Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis.

Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.

Filed under: Depression Treatment

PLoS One. 2013; 8(1): e54666
Nisticò R, Mango D, Mandolesi G, Piccinin S, Berretta N, Pignatelli M, Feligioni M, Musella A, Gentile A, Mori F, Bernardi… Continue reading