molecular mechanism

Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs.

Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs.

Filed under: Addiction Rehab

Adv Exp Med Biol. 2013; 734: 91-107
Bellovin DI, Das B, Felsher DW

Cancers are frequently addicted to initiating oncogenes that elicit aberrant cellular proliferation, self-renewal,… Continue reading

Depression Treatment: Vesicular Signalling and Immune Modulation as Hedonic Fingerprints: Proteomic Profiling in the Chronic Mild Stress Depression Model.

Vesicular signalling and immune modulation as hedonic fingerprints: proteomic profiling in the chronic mild stress depression model.

Filed under: Depression Treatment

J Psychopharmacol. 2012 Nov 8;
Bisgaard CF, Bak S, Christensen T, Jensen ON, Enghild JJ, Wiborg O

Extensive… Continue reading

Epigenetics-Beyond the Genome in Alcoholism.

Epigenetics-beyond the genome in alcoholism.

Filed under: Addiction Rehab

Alcohol Res. 2012; 34(3): 293-305
Starkman BG, Sakharkar AJ, Pandey SC

Genetic and environmental factors play a role in the development of alcoholism. Whole-genome expression profiling has highlighted the importance… Continue reading

Addiction Rehab: Alcohol Intoxication in the Context of Major Public Holidays, Sporting and Social Events: A Time-Series Analysis in Melbourne, Australia, 2000-2009.

Alcohol intoxication in the context of major public holidays, sporting and social events: A time-series analysis in Melbourne, Australia, 2000-2009.

Filed under: Addiction Rehab

Addiction. 2012 Nov 8;
Lloyd B, Matthews S, Livingston M, Jayasekara H, Smith K

AIMS:… Continue reading

Drug and Alcohol Rehabilitation: Gatifloxacin Induces S and G(2)-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via P21/p27/p53.

Gatifloxacin Induces S and G(2)-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2012; 7(10): e47796
Yadav V, Sultana S, Yadav J, Saini N

Pancreatic cancer, despite being the most… Continue reading

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators.

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2012; 7(10): e48591
Wong MV, Jiang S, Palasingam P, Kolatkar PR… Continue reading

On the Existence and Function of Galanin Receptor Heteromers in the Central Nervous System.

On the existence and function of galanin receptor heteromers in the central nervous system.

Filed under: Depression Treatment

Front Endocrinol (Lausanne). 2012; 3: 127
Fuxe K, Borroto-Escuela DO, Romero-Fernandez W, Tarakanov AO, Calvo F, Garriga P, Tena M, Narvaez… Continue reading

Depression Treatment: Clinical Patterns and Treatment Outcome in Patients With Melancholic, Atypical and Non-Melancholic Depressions.

Clinical patterns and treatment outcome in patients with melancholic, atypical and non-melancholic depressions.

Filed under: Depression Treatment

PLoS One. 2012; 7(10): e48200
Gili M, Roca M, Armengol S, Asensio D, Garcia-Campayo J, Parker G

To assess sociodemographic, clinical and… Continue reading

Recurrent Oral Cancer: Current and Emerging Therapeutic Approaches.

Recurrent oral cancer: current and emerging therapeutic approaches.

Filed under: Drug and Alcohol Rehabilitation

Front Pharmacol. 2012; 3: 149
da Silva SD, Hier M, Mlynarek A, Kowalski LP, Alaoui-Jamali MA

Oral cavity cancer (OCC) is associated with high incidence… Continue reading

Reprofiling a Classical Anthelmintic, Pyrvinium Pamoate, as an Anti-Cancer Drug Targeting Mitochondrial Respiration.

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.

Filed under: Drug and Alcohol Rehabilitation

Front Oncol. 2012; 2: 137
Ishii I, Harada Y, Kasahara T

Pyrvinium pamoate (PP) is an FDA-approved classical anthelmintic, but… Continue reading