metabotropic glutamate receptors
A Nine-Year Follow-Up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.
A Nine-Year Follow-up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.
Sleep. 2013; 36(8): 1187-98
Chen HC, Su TP, Chou P
To simultaneously explore the associations between mortality and insomnia, sleep duration, and the use of hypnotics in older adults.A fixed cohort study.A community in Shih-Pai area, Taipei, Taiwan.A total of 4,064 participants over the age of 65 completed the study.N/A.Insomnia was classified using an exclusionary hierarchical algorithm, which categorized insomnia as “no insomnia,” “subjective poor sleep quality,” “Pittsburgh Sleep Quality Index > 5 insomnia,” “1-month insomnia disorder,” and “6-month insomnia disorder.” The main outcome variables were 9-year all-cause mortality rates. In the all-cause mortality analyses, when hypnotic use, depressive symptoms and total sleep time were excluded from a proportional hazards regression model, subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” had a higher mortality risk (HR: 1.21, 95% CI: 1.01-1.45). In the full model, frequent hypnotic use and long sleep duration predicted higher mortality rates. However, the increased mortality risk for subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” was not observed in the full model. On the contrary, individuals with… Continue reading →
Metabotropic Glutamate Receptor 5 Within Nucleus Accumbens Shell Modulates Environment-Elicited Cocaine Conditioning Expression.
Metabotropic Glutamate Receptor 5 within Nucleus Accumbens Shell modulates environment-elicited cocaine conditioning expression.
Pharmacol Biochem Behav. 2013 Jul 9;
Martínez-Rivera A, Rodríguez-Borrero E, Matías-Alemán M, Montalvo-Acevedo A, Guerrero-Figuereo K, Febo-Rodriguez LJ, Morales-Rivera A, Maldonado-Vlaar CS
The metabotropic glutamate receptors… Continue reading →
Illuminating the Activation Mechanisms and Allosteric Properties of Metabotropic Glutamate Receptors.
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.
Proc Natl Acad Sci U S A. 2013 Mar 4;
Doumazane E, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P
In multimeric cell-surface receptors,… Continue reading →
Rescue of Infralimbic mGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence.
Rescue of Infralimbic mGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence.
Filed under: Addiction Rehab
J Neurosci. 2013 Feb 13; 33(7): 2794-806
Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher… Continue reading →
Understanding Addiction: Author Theresa Brown Responds.
Understanding addiction: author Theresa Brown responds.
Filed under: Addiction Rehab
Am J Nurs. 2013 Jan; 113(1): 12
Brown T
Rising taurine and ethanol concentrations in nucleus accumbens interact to produce the dopamine-activating effects of alcohol.… Continue reading →
Addiction Rehab: Inhibition of FAAH and Activation of PPAR: New Approaches to the Treatment of Cognitive Dysfunction and Drug Addiction.
Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction.
Filed under: Addiction Rehab
Pharmacol Ther. 2013 Jan 16;
Panlilio LV, Justinova Z, Goldberg SR
Enhancing the effects of endogenously-released cannabinoid… Continue reading →
Addiction Rehab: PET Imaging of Metabotropic Glutamate Receptor Subtype 5 (MGluR5).
PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5).
Filed under: Addiction Rehab
Am J Nucl Med Mol Imaging. 2012; 2(1): 29-32
Li D, Shan H, Conti P, Li Z
Metabotropic glutamate receptors (mGluRs) belong to a family of… Continue reading →
Group I Metabotropic Glutamate Receptor-Mediated Gene Transcription and Implications for Synaptic Plasticity and Diseases.
Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases.
Filed under: Addiction Rehab
Front Pharmacol. 2012; 3: 189
Wang H, Zhuo M
Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety… Continue reading →
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