metabotropic glutamate receptors

A Nine-Year Follow-Up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.

A Nine-Year Follow-up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.

Sleep. 2013; 36(8): 1187-98
Chen HC, Su TP, Chou P

To simultaneously explore the associations between mortality and insomnia, sleep duration, and the use of hypnotics in older adults.A fixed cohort study.A community in Shih-Pai area, Taipei, Taiwan.A total of 4,064 participants over the age of 65 completed the study.N/A.Insomnia was classified using an exclusionary hierarchical algorithm, which categorized insomnia as “no insomnia,” “subjective poor sleep quality,” “Pittsburgh Sleep Quality Index > 5 insomnia,” “1-month insomnia disorder,” and “6-month insomnia disorder.” The main outcome variables were 9-year all-cause mortality rates. In the all-cause mortality analyses, when hypnotic use, depressive symptoms and total sleep time were excluded from a proportional hazards regression model, subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” had a higher mortality risk (HR: 1.21, 95% CI: 1.01-1.45). In the full model, frequent hypnotic use and long sleep duration predicted higher mortality rates. However, the increased mortality risk for subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” was not observed in the full model. On the contrary, individuals with… Continue reading

Metabotropic Glutamate Receptor 5 Within Nucleus Accumbens Shell Modulates Environment-Elicited Cocaine Conditioning Expression.

Metabotropic Glutamate Receptor 5 within Nucleus Accumbens Shell modulates environment-elicited cocaine conditioning expression.

Pharmacol Biochem Behav. 2013 Jul 9;
Martínez-Rivera A, Rodríguez-Borrero E, Matías-Alemán M, Montalvo-Acevedo A, Guerrero-Figuereo K, Febo-Rodriguez LJ, Morales-Rivera A, Maldonado-Vlaar CS

The metabotropic glutamate receptors… Continue reading

Illuminating the Activation Mechanisms and Allosteric Properties of Metabotropic Glutamate Receptors.

Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors.

Proc Natl Acad Sci U S A. 2013 Mar 4;
Doumazane E, Scholler P, Fabre L, Zwier JM, Trinquet E, Pin JP, Rondard P

In multimeric cell-surface receptors,… Continue reading

Rescue of Infralimbic mGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence.

Rescue of Infralimbic mGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence.

Filed under: Addiction Rehab

J Neurosci. 2013 Feb 13; 33(7): 2794-806
Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher… Continue reading

Understanding Addiction: Author Theresa Brown Responds.

Understanding addiction: author Theresa Brown responds.

Filed under: Addiction Rehab

Am J Nurs. 2013 Jan; 113(1): 12
Brown T

HubMed – addiction

 

Rising taurine and ethanol concentrations in nucleus accumbens interact to produce the dopamine-activating effects of alcohol.… Continue reading

Addiction Rehab: Inhibition of FAAH and Activation of PPAR: New Approaches to the Treatment of Cognitive Dysfunction and Drug Addiction.

Inhibition of FAAH and activation of PPAR: New approaches to the treatment of cognitive dysfunction and drug addiction.

Filed under: Addiction Rehab

Pharmacol Ther. 2013 Jan 16;
Panlilio LV, Justinova Z, Goldberg SR

Enhancing the effects of endogenously-released cannabinoid… Continue reading

Addiction Rehab: PET Imaging of Metabotropic Glutamate Receptor Subtype 5 (MGluR5).

PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5).

Filed under: Addiction Rehab

Am J Nucl Med Mol Imaging. 2012; 2(1): 29-32
Li D, Shan H, Conti P, Li Z

Metabotropic glutamate receptors (mGluRs) belong to a family of… Continue reading

Group I Metabotropic Glutamate Receptor-Mediated Gene Transcription and Implications for Synaptic Plasticity and Diseases.

Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases.

Filed under: Addiction Rehab

Front Pharmacol. 2012; 3: 189
Wang H, Zhuo M

Stimulation of group I metabotropic glutamate receptors (mGluRs) initiates a wide variety… Continue reading