Synthesis and in Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT(7) Receptor Imaging With PET.
Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT(7) Receptor Imaging with PET.
Filed under: Drug and Alcohol Rehabilitation
ACS Chem Neurosci. 2012 Dec 19; 3(12): 1002-7
Herth MM, Volk B, Pallagi K, Kofoed Bech… Continue reading
Synthesis and in Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT(7) Receptor Imaging With PET.
Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT(7) Receptor Imaging with PET.
Filed under: Drug and Alcohol Rehabilitation
ACS Chem Neurosci. 2012 Dec 19; 3(12): 1002-7
Herth MM, Volk B, Pallagi K, Kofoed Bech… Continue reading
Drug and Alcohol Rehabilitation: Odyssey of a Cancer Nanoparticle: From Injection Site to Site of Action.
Odyssey of a cancer nanoparticle: from injection site to site of action.
Filed under: Drug and Alcohol Rehabilitation
Nano Today. 2012 Dec 1; 7(6): 606-618
Nichols JW, Bae YH
No chemotherapeutic drug can be effective until it is delivered… Continue reading
BIOMARKERS of OPERATIONAL TOLERANCE in SOLID ORGAN TRANSPLANTATION.
BIOMARKERS OF OPERATIONAL TOLERANCE IN SOLID ORGAN TRANSPLANTATION.
Filed under: Drug and Alcohol Rehabilitation
Expert Opin Med Diagn. 2012 Jul; 6(4): 281-293
Heidt S, Wood KJ
INTRODUCTION: Long-term immunosuppressive therapy represents a huge burden on transplant recipients, but currently… Continue reading
A Potential in Vitro and in Vivo Anti-HIV Drug Screening System for Chinese Herbal Medicines.
A potential in vitro and in vivo anti-HIV drug screening system for Chinese herbal medicines.
Filed under: Drug and Alcohol Rehabilitation
Phytother Res. 2012 Jun; 26(6): 899-907
Feng L, Wang L, Ma YY, Li M, Zhao GQ
Chinese herbal medicines are often applied as an alternative therapy for viral diseases. However, the development of anti-HIV herbal drugs has proceeded slowly, partly because of the lack of a high-throughput system for screening these drugs. The present study evaluated 16 herbal medicines for anti-HIV activities in vitro and in vivo. Herbal medicines were first screened for the ability to regulate C-X-C receptor 4 (CXCR4) and C-C receptor 5 (CCR5) promoter activities. A single-round pseudotyped HIV-luciferase reporter virus system (HIV-Luc) was used to identify potential anti-HIV mechanisms. CD4+ T cells from healthy volunteers were examined for changes in CXCR4 and CCR5 levels. HIV-1 replication was evaluated by ELISA. Spica Prunellae and Herba Andrographitis were found to down-regulate the activities of both the CXCR4 and CCR5 promoters. Also, Spica Prunellae and Herba Andrographitis (>1000 ?M)… Continue reading