Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.
Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing.
PLoS One. 2013; 8(2): e57140
Kandeel M, Kitade Y
RNA interference (RNAi) is a highly specialized process of protein-siRNA interaction… Continue reading
Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus Aureus to Pentacyclic Triterpenoids.
Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus aureus to Pentacyclic Triterpenoids.
PLoS One. 2013; 8(2): e56687
Chung PY, Chung LY, Navaratnam P
Staphylococcus aureus is an important human pathogen in both hospital and the community that has demonstrated… Continue reading
Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease – Novel Clues to Drug Targets and Disease Mechanisms?
Gene expression and thiopurine metabolite profiling in inflammatory bowel disease – novel clues to drug targets and disease mechanisms?
PLoS One. 2013; 8(2): e56989
Haglund S, Almer S, Peterson C, Söderman J
Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy. Here we explored the molecular basis of differences in metabolite profiles and in relation to disease activity.Transcriptional profiles in blood samples from an exploratory IBD-patient cohort (n?=?21) with a normal thiopurine S-methyltransferase phenotype and meTIMP/6-TGN ratios >20, 10.0-14.0 and ?4, respectively, were assessed… Continue reading
Transcriptional Mechanisms of Drug Addiction.
Transcriptional mechanisms of drug addiction.
Clin Psychopharmacol Neurosci. 2012 Dec; 10(3): 136-43
Nestler EJ
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription… Continue reading
Drug and Alcohol Rehabilitation: GL3, a Novel 4?-Anilino-4′-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities.
GL3, a Novel 4?-Anilino-4′-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities.
Filed under: Drug and Alcohol Rehabilitation
Transl Oncol. 2013 Feb; 6(1): 75-82
Yang XC, Qian SJ, Wang L, Liao SD, Cao J, Hu YZ, He… Continue reading