drug design

Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease.

Brain-Penetrant Tetrahydronaphthalene Thromboxane A2-Prostanoid (TP) Receptor Antagonists as Prototype Therapeutics for Alzheimer’s Disease.

Filed under: Drug and Alcohol Rehabilitation

ACS Chem Neurosci. 2012 Nov 21; 3(11): 928-40
Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ,… Continue reading

Metformin and the Risk of Cancer: Time-Related Biases in Observational Studies.

Metformin and the Risk of Cancer: Time-related biases in observational studies.

Filed under: Drug and Alcohol Rehabilitation

Diabetes Care. 2012 Dec; 35(12): 2665-73
Suissa S, Azoulay L

OBJECTIVE Time-related biases in observational studies of drug effects have been described… Continue reading

Structural and Binding Properties of Two Paralogous Fatty Acid Binding Proteins of Taenia Solium Metacestode.

Structural and Binding Properties of Two Paralogous Fatty Acid Binding Proteins of Taenia solium Metacestode.

Filed under: Drug and Alcohol Rehabilitation

PLoS Negl Trop Dis. 2012 Oct; 6(10): e1868
Kim SH, Bae YA, Yang HJ, Shin JH, Diaz-Camacho SP,… Continue reading

Effect of Bile Acid Sequestrants on Glycaemic Control: Protocol for a Systematic Review With Meta-Analysis of Randomised Controlled Trials.

Effect of bile acid sequestrants on glycaemic control: protocol for a systematic review with meta-analysis of randomised controlled trials.

Filed under: Drug and Alcohol Rehabilitation

BMJ Open. 2012; 2(6):
Hansen M, Sonne DP, Mikkelsen KH, Gluud LL, Vilsbøll T,… Continue reading

In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment.

In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment.

Filed under: Drug and Alcohol Rehabilitation

J Biomed Biotechnol. 2012; 2012: 714623
Behera DK, Behera PM, Acharya… Continue reading

Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art.

Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art.

Filed under: Drug and Alcohol Rehabilitation

J Oncol. 2012; 2012: 234726
Lebastchi AH, Kunstman JW, Carling T

Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy that generally conveys a poor prognosis. Currently, surgical resection… Continue reading

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators.

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2012; 7(10): e48591
Wong MV, Jiang S, Palasingam P, Kolatkar PR… Continue reading

Drug and Alcohol Rehabilitation: MycPermCheck: The Mycobacterium Tuberculosis Permeability Prediction Tool for Small Molecules.

MycPermCheck: The Mycobacterium tuberculosis permeability prediction tool for small molecules.

Filed under: Drug and Alcohol Rehabilitation

Bioinformatics. 2012 Oct 25;
Merget B, Zilian D, Müller T, Sotriffer CA

MOTIVATION: With over 8 million new cases in 2010, particularly documented… Continue reading