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The Story of Glutamate in Drug Addiction and of N-Acetylcysteine as a Potential Pharmacotherapy.

The Story of Glutamate in Drug Addiction and of N-Acetylcysteine as a Potential Pharmacotherapy.

JAMA Psychiatry. 2013 Jul 31;
Brown RM, Kupchik YM, Kalivas PW

HubMed – addiction

Pharmacological interventions to modulate attentional bias in addiction.

CNS Spectr.… Continue reading

Unintentional Weakness of Cancers: The MEK/ERK Pathway as a Double-Edged Sword.

Unintentional weakness of cancers: the MEK/ERK pathway as a double-edged sword.

Mol Cancer Res. 2013 Jul 30;
Suda K, Mitsudomi T

Recent advances in molecular target therapy have greatly improved treatment outcomes for cancers driven by oncogenic mutations. However… Continue reading

Current and Emerging Treatments for Absence Seizures in Young Patients.

Current and emerging treatments for absence seizures in young patients.

Neuropsychiatr Dis Treat. 2013; 9: 963-75
Vrielynck P

In this report, we review the pharmacological and non-pharmacological treatments of the different absence seizure types as recently recognized by the… Continue reading

Hepatoprotective and Antioxidant Effects of Saponarin, Isolated From Gypsophila Trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats.

Hepatoprotective and Antioxidant Effects of Saponarin, Isolated from Gypsophila trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats.

Biomed Res Int. 2013; 2013: 757126
Simeonova R, Vitcheva V, Kondeva-Burdina M, Krasteva I, Manov V, Mitcheva M

The hepatoprotective potential of… Continue reading

The Role of the Aversive Effects of Drugs in Self-Administration: Assessing the Balance of Reward and Aversion in Drug-Taking Behavior.

The role of the aversive effects of drugs in self-administration: assessing the balance of reward and aversion in drug-taking behavior.

Behav Pharmacol. 2013 Jul 16;
Verendeev A, Riley AL

Since the first experimental demonstration that a drug of abuse… Continue reading

Bisphosphonate Drug Holiday: Who, When and How Long.

Bisphosphonate drug holiday: who, when and how long.

Ther Adv Musculoskelet Dis. 2013 Jun; 5(3): 107-11
Diab DL, Watts NB

Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from numerous placebo-controlled trials demonstrating efficacy… Continue reading

Identification of (2-Aminopropyl)indole Positional Isomers in Forensic Samples.

Identification of (2-aminopropyl)indole positional isomers in forensic samples.

Drug Test Anal. 2013 Jul 8;
Scott KR, Power JD, McDermott SD, O’Brien JE, Talbot BN, Barry MG, Kavanagh PV

In 2012, 5-(2-aminopropyl)indole (5-API, 5-IT) was reported by Norwegian authorities to… Continue reading

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay.

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Science. 2013 Jul 5; 341(6141): 84-7
Molina DM, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P

The… Continue reading

Exploring the Ligand-Protein Networks in Traditional Chinese Medicine: Current Databases, Methods, and Applications.

Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods, and applications.

Evid Based Complement Alternat Med. 2013; 2013: 806072
Zhao M, Zhou Q, Ma W, Wei DQ

The traditional Chinese medicine (TCM), which has thousands of years… Continue reading

Exceptions to and Deviations From the INN Common Stem System.

Exceptions to and deviations from the INN common stem system.

Prescrire Int. 2013 May; 22(138): 138-9

For various reasons, mainly related to the history of the drug and of drug nomenclature, some INNs lack a common stem. As INN… Continue reading