Antiviral Drug

Calibration Technologies for Correct Determination of Epstein-Barr Virus, Human Herpesvirus 6 (HHV-6), and HHV-8 Antiviral Drug Susceptibilities by Use of Real-Time-PCR-Based Assays.

Published May 21, 2013

Calibration Technologies for Correct Determination of Epstein-Barr Virus, Human Herpesvirus 6 (HHV-6), and HHV-8 Antiviral Drug Susceptibilities by Use of Real-Time-PCR-Based Assays.

J Clin Microbiol. 2013 Jun; 51(6): 2013
Broccolo F, Lusso P, Malnati M

HubMed – drug

… Continue reading →

Delirium Associated With Donepezil in a Patient With Alzheimer’s Disease: A Case Report.

Published May 21, 2013

Delirium associated with donepezil in a patient with Alzheimer’s disease: a case report.

Iran J Psychiatry. 2013 Mar; 8(1): 59-60
Mollazadeh-Moghaddam K, Jamali A, Adili-Aghdam F, Akhondzadeh S

Donepezil, a member of the acetylcholinesterase inhibitor family, is approved for… Continue reading →

Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration.

Published May 3, 2013

Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration.

Front Oncol. 2013; 3: 93
Loh AH, Brennan RC, Lang WH, Hickey RJ, Malkas LH, Sandoval JA

Children with solid tumors represent a unique population.… Continue reading →

Reliability of Classifying Multiple Sclerosis Disease Activity Using Magnetic Resonance Imaging in a Multiple Sclerosis Clinic.

Published April 20, 2013

Reliability of classifying multiple sclerosis disease activity using magnetic resonance imaging in a multiple sclerosis clinic.

JAMA Neurol. 2013 Mar 1; 70(3): 338-44
Erbayat Altay E, Fisher E, Jones SE, Hara-Cleaver C, Lee JC, Rudick RA

To assess the… Continue reading →

Preparation of Biocompatible Carboxymethyl Chitosan Nanoparticles for Delivery of Antibiotic Drug.

Published April 16, 2013

Preparation of biocompatible carboxymethyl chitosan nanoparticles for delivery of antibiotic drug.

Biomed Res Int. 2013; 2013: 236469
Zhao L, Zhu B, Jia Y, Hou W, Su C

Objective. To prepare biocompatible ciprofloxacin-loaded carboxymethyl chitosan nanoparticles (CCC NPs) and evaluate… Continue reading →

HIV Treatments Have Malaria Gametocyte Killing and Transmission Blocking Activity.

Published March 30, 2013

HIV Treatments have Malaria Gametocyte Killing and Transmission Blocking Activity.

J Infect Dis. 2013 Mar 28;
Hobbs CV, Tanaka TQ, Muratova O, Van Vliet J, Borkowsky W, Williamson KC, Duffy PE

Background.?Millions of individuals being treated for HIV live… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity Against Respiratory Syncytial Virus.

Published March 6, 2013

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus.

PLoS One. 2013; 8(2): e56762
Geller R, Andino R, Frydman J

Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children, leading to significant morbidity… Continue reading →

Macromolecular Prodrugs of Ribavirin Combat Side Effects and Toxicity With No Loss of Activity of the Drug.

Published February 23, 2013

Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug.

Chem Commun (Camb). 2013 Feb 22;
Kryger MB, Wohl BM, Smith AA, Zelikin AN

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT… Continue reading →

Drug and Alcohol Rehabilitation: The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes.

Published January 27, 2013

The hepatitis B virus ribonuclease h is sensitive to inhibitors of the human immunodeficiency virus ribonuclease h and integrase enzymes.

Filed under: Drug and Alcohol Rehabilitation

PLoS Pathog. 2013 Jan; 9(1): e1003125
Tavis JE, Cheng X, Hu Y, Totten… Continue reading →