Susceptibility Genes Are Enriched in Those of the HSV-1/host Interactome in Psychiatric and Neurological Disorders.
Susceptibility genes are enriched in those of the HSV-1/host interactome in psychiatric and neurological disorders.
Pathog Dis. 2013 Aug 3;
Carter CJ
Herpes simplex (HSV-1) can promote beta-amyloid deposition and tau phosphorylation, demyelination or cognitive deficits relevant to Alzheimer’s disease or multiple sclerosis and to many neuropsychiatric disorders with which it has been implicated. A seroprevalence much higher than disease incidence has called into question any primary causal role. However, as also the case with risk promoting polymorphisms, (also present in control populations) any causal effects are likely to be conditional. During its life cycle, the virus binds to many proteins and modifies the expression of multiple genes creating a host/pathogen interactome involving 1347 host genes. This dataset is heavily enriched in the susceptibility genes for multiple sclerosis (P= 1.3E-99) >Alzheimer’s disease > schizophrenia > Parkinsonism > depression> bipolar disorder> childhood obesity> chronic fatigue> autism > and anorexia (P=0.047) but not ADHD, a relationship maintained for GWAS datasets in multiple sclerosis and Alzheimer’s… Continue reading
Use of Micronutrients Attenuates Cannabis and Nicotine Abuse as Evidenced From a Reversal Design: A Case Study.
Use of micronutrients attenuates cannabis and nicotine abuse as evidenced from a reversal design: a case study.
J Psychoactive Drugs. 2013 Apr-Jun; 45(2): 168-78
Harrison R, Rucklidge JJ, Blampied N
Prior research shows that micronutrients, particularly amino acids, can… Continue reading
Zinc Homeostasis and Neurodegenerative Disorders.
Zinc homeostasis and neurodegenerative disorders.
Front Aging Neurosci. 2013; 5: 33
Szewczyk B
Zinc is an essential trace element, whose importance to the function of the central nervous system (CNS) is increasingly being appreciated. Alterations in zinc dyshomeostasis has… Continue reading
Clinical Approach to Fever in the Neurosurgical Intensive Care Unit: Focus on Drug Fever.
Clinical approach to fever in the neurosurgical intensive care unit: Focus on drug fever.
Surg Neurol Int. 2013; 4(Suppl 5): S318-22
Cunha BA
As fever is one of the cardinal signs of infection, the presence of fever in a patient in the neurosurgical intensive care unit (NSICU) raises the question of whether it is infectious in etiology. Infectious and noninfectious causes of fever in the NSICU may be determined based upon assessment of clinical signs and symptoms, the degree of temperature elevation, the relationship of the pulse to the fever (e.g., an infectious process resulting in hyperpyrexia and bradycardia), and when the fever occurs (e.g., related to the length of stay in the NSICU). There are many noninfectious disorders which contribute to temperatures >102°F in the NSICU; these include drug fevers, deep vein thrombosis, phlebitis/pulmonary embolism, acute myocardial infarction, atelectasis, dehydration, acute gout flare, malignancy, acute pancreatitis, transfusion associated hepatitis, and hemorrhage. Infectious rather than noninfectious disorders, however, are more typically associated with high-grade fevers (>102°F.) in the NSICU, and nosocomial pneumonia, (synonymous with ventilator-associated pneumonia [VAP]), is the leading culprit,… Continue reading
A Depressive Endophenotype of Mild Cognitive Impairment and Alzheimer’s Disease.
A depressive endophenotype of mild cognitive impairment and Alzheimer’s disease.
PLoS One. 2013; 8(7): e68848
Johnson LA, Hall JR, O’Bryant SE
Alzheimer’s disease (AD) is a devastating public health problem that affects over 5.4 million Americans. Depression increases the… Continue reading