Sertraline and Its Iodine Product: Experimental and Theoretical Vibrational Studies: Potential in Vitro Anti-Thyroid Activity of Sertraline and Iodine Product Toxicity With Respect to Male Wistar Rats.

Sertraline and its iodine product: Experimental and theoretical vibrational studies: Potential in vitro anti-thyroid activity of sertraline and iodine product toxicity with respect to male Wistar rats.

Filed under: Depression Treatment

Spectrochim Acta A Mol Biomol Spectrosc. 2012 Dec 4; 104C: 271-279
Escudero GE, Ferraresi Curotto V, Laino CH, Pis Diez R, Williams PA, Ferrer EG

Mayor depression, obsessive-compulsive panic, social anxiety disorders are common diseases that are usually treated with sertraline hydrochloride which is the active ingredient of the well known drugs as Zoloft and Lustral. In this work, we presented a more complete vibrational characterization of the solid phase FT-IR spectra of Sertraline hydrochloride and its sertraline-iodine product in which the conformational space of the molecules was investigated performing molecular dynamic simulations within an NVT ensemble. Geometrical, electronic and vibrational properties were calculated with the density functional theory. Comparison of the simulated spectra with the experimental spectra provides important information about the ability of the computational method to describe the vibrational modes of both molecules. In addition, for the first time we present the evaluation of anti-thyroid activity of sertraline hydrochloride by using the Lang’s method. Also, with the aim to evaluate the antidepressant effect of its iodine product we demonstrated for this compound the toxic effect towards the male Wistar rats.
HubMed – depression


Activation of Extrasynaptic NMDA Receptors induces LTD in Rat Hippocampal CA1 Neurons.

Filed under: Depression Treatment

Brain Res Bull. 2012 Dec 24;
Liu DD, Yang Q, Li ST

In the adult rat hippocampus, activation of N-methyl-D-aspartate receptors (NMDARs) is required for the induction of certain forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Several studies have indicated the opposing role of synaptic NMDARS (S-NMDARs) versus extrasynaptic NMDARs (ES-NMDARs) in CREB-dependent gene regulation and neuronal survival/death. The contribution of ES-NMDARs in synaptic plasticity, however, remains unclear. Here we investigated the contribution of ES-NMDARs on LTD induction in CA1 neurons of rat hippocampal slices. ES-NMDARs were selectively activated by theta burst stimulation (TBS) after selective blockade of S-NMDARs with pairing of 5Hz stimulation and MK-801, an irreversible use-dependent antagonist of NMDARs. Application of TBS in naïve slices evoked a transient potentiation. In contrast, the activation of ES-NMDARs evoked a robust LTD. These results suggest the involvement of ES-NMDARs in LTD induction.
HubMed – depression


Anxiety and depression as markers of multiplicity of sites of functional gastrointestinal disorders: A gender issue?

Filed under: Depression Treatment

Clin Res Hepatol Gastroenterol. 2012 Dec 24;
Bouchoucha M, Hejnar M, Devroede G, Babba T, Bon C, Benamouzig R

BACKGROUND: Anxiety and depression are frequently present in patients with different types of functional gastrointestinal disorders (FGID), and seem to play a major part in both the perception of symptoms and the outcome of treatment. AIMS: The aim of the present study was therefore to evaluate levels of anxiety and depression in adult patients according to the extent and the type of FGID. METHODS: Three hundred and eighty-five consecutive patients (72% female) were evaluated. Each patient filled a standard clinical questionnaire based on diagnostic questions for uro-genital complaints and for FGID according to the Rome III criteria. In addition, they indicated on a 10-cm visual analog scale (VAS) the intensity of constipation, diarrhea, bloating, and abdominal pain, and stool description using the Bristol Stool Form Scale. Anxiety and depression were evaluated using Beck Depression Inventory and Anxiety State and Trait Anxiety Inventory. RESULTS: In FGID patients, levels of depression, state and trait anxiety are higher in patients with several sites of complaint. Females are more depressed than males, regardless of the level of FGID. Females tend to react emotionally to stress with a lot of anxiety (“state” anxiety), as well as in the long run (“trait” anxiety). VAS parameters for constipation, bloating and abdominal pain were related to psychological scores in contrast to VAS diarrhea and stool form. In males, the extent of sites of FGID was strongly related to trait anxiety. In females, it was strongly related to depression. CONCLUSION: Different types of FGID are associated with depression and anxiety according to the number of sites of complaints linked to gender and psychological parameters, as well as the magnitude of complaint expressed by the VAS.
HubMed – depression



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