SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses.

SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses.

Filed under: Depression Treatment

Neural Plast. 2012; 2012: 352829
Takagi H, Setou M, Ito S, Yao I

SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
HubMed – depression


Dental caries prevalence and tooth loss in chilean adult population: first national dental examination survey.

Filed under: Depression Treatment

Int J Dent. 2012; 2012: 810170
Urzua I, Mendoza C, Arteaga O, Rodríguez G, Cabello R, Faleiros S, Carvajal P, Muñoz A, Espinoza I, Aranda W, Gamonal J

The purpose of this study was to assess the prevalence of dental caries, tooth loss, and risk factors among adult population of Chile. Furthermore, age, gender, and behavioural specific differences in caries prevalence and tooth loss were examined. A national stratified multistage probabilistic sample design in two-age cohorts was applied to the Chilean population. A sample of 1553 adults, comprising 1088 individuals aged 35-44 and 465 senior individuals aged 65-74, were examined. The DMFT was evaluated following WHO recommendations using diagnostic criteria of caries lesions into dentin. The data were analyzed by univariate and multivariate models using logistic regression analyses. Results showed a mean DMFT of 15.06 in the 35-44-year-old group and of 21.57 in the 65-74 group. Factors related to tooth loss in the 35-44 group through univariate logistic regression were depression (OR 1.9 CI 95% 1.26-2.85), education level <12 years (OR 2.24 CI 95% 1.31-3.73), personal income (OR 1.51 CI 95% 1.04-2.19), and familiar income (OR 2.05 CI 95% 1.34-3.13), and through multivariate logistic regression in the same age group were depression (OR 1.93 CI 95% 1.24-3.0), education level <12 years (OR 1.94 CI 95% 1.2-3.14), and familiar income (OR 1.71 CI 95% 1.09-2.68). Factors related to tooth loss in the 65-74-year-old group through univariate logistic regression were education level <12 years (OR 2.54 CI 95% 1.3-4.96) and personal income (OR 1.66 CI 95% 1.05-2.63), and for multivariate logistic regression in the same age group, it was education level <12 years (OR 2.51 CI 95% 1.21-5.18). In conclusion, adult population in Chile showed a high prevalence of dental caries and tooth loss, as age, education level, personal and familiar incomes, and depression are being the main risk factors. HubMed – depression


Self perceived emotional functioning of spanish patients with amyotrophic lateral sclerosis: a longitudinal study.

Filed under: Depression Treatment

Front Psychol. 2012; 3: 609
Mora JS, Salas T, Fajardo ML, Iváñez L, Rodríguez-Santos F

Background: ALS is a neurodegenerative disease of the entire motor system that most frequently ends with respiratory arrest in few years. Its diagnosis and the rapid progression of the motor dysfunctions produce a continued emotional impact. Studies on this impact are helpful to plan adequate psychotherapeutic strategies. Objective: To assess and analyze: First: How the patients with ALS perceive their emotional health. Second: The emotional impact of their physical disabilities. Third: The physical disabilities with highest emotional impact. Fourth: The feelings with highest emotional impact. Methods: Up to 110 Spanish patients with ALS were assessed less than 1?year from diagnosis, then twice more at 6?month intervals, using the ALS Quality of Life Assessment Questionnaire (ALSAQ-40) validated for use in Spanish. Descriptive analysis and correlation between variables were obtained. Results: Worries about the future, of lack of freedom, and of being a burden were prevalent feelings. On average depression was felt only “sometimes.” Only 25% of the variations in the emotional state were explained by changes in the physical state at first evaluation, and 16% at the last one. Emotional functioning correlated significantly with the physical disabilities at first and second evaluation, less so at third. Communication disabilities always had the highest impact. Depression at first evaluation and hopelessness at the next two evaluations had the highest emotional impact. Hopelessness did not correlate with any physical disability at the third evaluation. On the whole, emotional dysfunction was self perceived as intermediate (between none and worst), and remained stable at 1?year follow up, in both bulbar and spinal onset patients. Conclusions: Physical dysfunctions per se have a limited role in patients´ emotional distress. Communication disabilities, as well as feelings of depression at early stages of illness, and of hopelessness later on, had the most impact. This requires their careful therapeutic attention. On average, Spanish patients with ALS cope with their disease, overcoming depression, which is not felt often, and with just mid levels of emotional dysfunction.
HubMed – depression


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