Psychosocial Factors Associated With Depressive Mood in Israeli Obese Adolescents.

Psychosocial Factors Associated with Depressive Mood in Israeli Obese Adolescents.

J Health Psychol. 2013 Mar 11;
Yackobovitch-Gavan M, Meshy-Tamir R, Nagelberg N, Phillip M, Meyerovitch J

This study aimed to compare levels of depressive symptoms between normal-weight and obese Israeli adolescents and to identify sociodemographic factors that may explain differences in depression between these groups. Thirty normal-weight and 49 obese patients aged 12-18 years participated in this study. The obese group had a significantly higher depression score. On linear regression analysis, obesity, lower parental income, and lower self-esteem were significantly associated with a higher depression score. This model explained 32.4 percent of the variance. The results indicate that psychosocial assessment and identification of depressive signs should be considered integral components in the management of adolescent obesity. HubMed – depression


Predictors of Fatigue in Cancer Patients Before and After Chemotherapy.

J Health Psychol. 2013 Mar 11;
Pertl M, Hevey D, Collier S, Lambe K, O’Dwyer AM

Fatigue is a debilitating and common condition in cancer patients. This study examined pretreatment predictors of fatigue before chemotherapy and also assessed whether these could prospectively predict fatigue posttreatment. A total of 100 patients completed questionnaires assessing psychological factors, physical activity and sleep. A subsample of 26 participants wore actigraphs to objectively assess sleep/wake and activity/rest. Fatigue was measured pretreatment and posttreatment and at follow-up several months later. Greater pretreatment pain, depression, stress and sleep disruption significantly predicted greater fatigue before chemotherapy, explaining 55 percent of the variance. Pretreatment fatigue significantly predicted posttreatment fatigue. No other significant prospective predictors of posttreatment fatigue emerged. HubMed – depression


Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood.

Neuropsychopharmacology. 2013 Mar 11;
Suo L, Zhao L, Si J, Liu J, Zhu W, Chai B, Zhang Y, Feng J, Ding Z, Luo Y, Shi H, Shi J, Lu L

Stress in adolescence has been widely demonstrated to have a lasting impact in humans and animal models. Developmental risk and protective factors play an important role in the responses to stress in adulthood. Mild-to-moderate stress in adolescence may resist the negative impacts of adverse events in adulthood. However, little research on resilience has been conducted. In the present study, we used a predictable chronic mild stress (PCMS) procedure (5 min of daily restraint stress for 28 days) in adolescent rats (postnatal days 28-55) to test the resilience effect of PCMS on depressive-like behavior in the sucrose preference test and forced swim test and anxiety-like behavior in the novelty-suppressed feeding test and elevated plus maze in adulthood. We also investigated the role of mammalian target of rapamycin (mTOR) signaling in the brain during the PCMS procedure in adolescence. Moreover, we investigated the effect of PCMS in adolescence on subsequent responses to chronic unpredictable stress (CUS; postnatal days 63-83) in adulthood. The results demonstrated that PCMS during adolescence produced antidepressant- and anxiolytic-like effects and increased mTOR signaling activity in the prefrontal cortex in early adulthood. Either systemic administration or intra-PFC infusion of the mTOR inhibitor rapamycin completely blocked the behavioral effects produced by PCMS in adolescence. PCMS during adolescence resisted depressive- and anxiety-like behavior caused by CUS in adulthood. These findings indicate that PCMS in adolescence can contribute to resilience against depression and anxiety caused by stress in adulthood.Neuropsychopharmacology accepted article preview online, 11 March 2013; doi:10.1038/npp.2013.67. HubMed – depression


Impact of Fatigue on Psychological Outcomes in Adults Living With Rheumatoid Arthritis.

Nurs Res. 2013 Mar 8;
Franklin AL, Harrell TH

BACKGROUND:: Fatigue has been shown to be a prevalent symptom in patients with rheumatoid arthritis, having a negative impact on health-related quality of life. However, aside from depression, related fatigue has not been linked to specific psychological outcomes and is not a common target in treatment programs. OBJECTIVES:: The aim of the study was to examine the unique influence of rheumatoid arthritis-related fatigue on three psychological outcomes: depressive symptoms, perceived health impairment, and satisfaction with abilities. METHODS:: In a large (n = 200) convenience sample of older adults who provided informed consent, multiple regression analyses were conducted to determine the direct and unique impact of demographic variables, functional impairment, pain, and fatigue on each of three psychological outcomes: depressive symptoms, perceived health impairment, and satisfaction with ability. RESULTS:: Fatigue significantly and uniquely contributed to each of the psychological outcomes, above and beyond pain and functional impairment. The variances of depressive symptoms, perceived health impairment, and satisfaction with ability accounted for by fatigue were highly significant. DISCUSSION:: The study indicates that rheumatoid arthritis-related fatigue contributes to diminished psychological well-being in older adults aging with rheumatoid arthritis and suggests the need for psychoeducational and management strategies that specifically target fatigue as part of an overall rheumatoid arthritis management program. Future research should attempt to obtain a larger sample of male and younger patients to determine if there are significant gender and age differences in the impact of fatigue on psychological outcomes. HubMed – depression



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