Preliminary Psychometrics of the Neurological Disorders Depression Inventory for Epilepsy-Youth.

Preliminary Psychometrics of the Neurological Disorders Depression Inventory for Epilepsy-Youth.

J Child Neurol. 2013 Apr 10;
Wagner JL, Smith G, Ferguson PL, Fedele DA

The authors examined the preliminary psychometrics of a depression screening tool for youth with epilepsy. Development involved content analysis, cognitive interviewing, and qualitative analysis. Ninety-three youths with epilepsy aged 10 to 17 years completed the Neurological Disorders Depression Inventory for Epilepsy-Youth and the depression module of a standardized clinical interview. Caregivers rated seizure severity and completed the Pediatric Symptom Checklist. Results indicated strong reliability indices, including test-retest, ? value, and internal consistency for the Neurological Disorders Depression Inventory for Epilepsy-Youth. It was significantly associated with the other measures of depression and psychosocial functioning. Factor analyses revealed a 1-factor solution for 9 items, with 35.7% of the variance explained. An optimal cutoff score of 27 resulted in a sensitivity index of 0.80 and a specificity index of 0.71. The Neurological Disorders Depression Inventory for Epilepsy-Youth is a screening tool that can be utilized in routine epilepsy care, but further evaluation is necessary. HubMed – depression


Depression and anxiety issue information.

Depress Anxiety. 2013 Apr; 30(4): na

HubMed – depression


[Intracavernous injection: a treatment modality for erectile dysfunction].

Hautarzt. 2013 Apr; 64(4): 232-3
Uche-Holub E, Thierling U, Giessing M, Neumann NJ

A 56-year-old man presented with a 12-year history of erectile dysfunction, which caused him extreme distress with episodes of depression. Attempts with sildenafil did not improve his erections. We tried intracavernous injection of alprostadil which enabled the patient to achieve a moderate erection. Thus, we instructed the patient for self-injection, which led to sufficient erections over the following months. We then restarted with tadalafil as a monotherapy which then was successful. HubMed – depression


Joint modeling compliance and outcome for causal analysis in longitudinal studies.

Stat Med. 2013 Apr 9;
Gao X, Brown GK, Elliott MR

This article discusses joint modeling of compliance and outcome for longitudinal studies when noncompliance is present. We focus on two-arm randomized longitudinal studies in which subjects are randomized at baseline, treatment is applied repeatedly over time, and compliance behaviors and clinical outcomes are measured and recorded repeatedly over time. In the proposed Markov compliance and outcome model, we use the potential outcome framework to define pre-randomization principal strata from the joint distribution of compliance under treatment and control arms, and estimate the effect of treatment within each principal strata. Besides the causal effect of the treatment, our proposed model can estimate the impact of the causal effect of the treatment at a given time on future compliance. Bayesian methods are used to estimate the parameters. The results are illustrated using a study assessing the effect of cognitive behavior therapy on depression. A simulation study is used to assess the repeated sampling properties of the proposed model. Copyright © 2013 John Wiley & Sons, Ltd. HubMed – depression