Multiple Primary Cancer Survivors Have Poorer Health Status and Well-Being Than Single Primary Cancer Survivors: A Study From the Population-Based PROFILES Registry.

Multiple primary cancer survivors have poorer health status and well-being than single primary cancer survivors: a study from the population-based PROFILES registry.

Filed under: Depression Treatment

Psychooncology. 2012 Dec 2;
Thong MS, Mols F, Verhoeven RH, Liu L, Andrykowski MA, Roukema JA, van de Poll-Franse LV

OBJECTIVE: The health status and psychosocial well-being of multiple primary cancer (MPC) survivors are under-researched. METHODS: In total, 3615 survivors identified from the Eindhoven Cancer Registry between 2008 and 2009 were assessed. About one in six survivors had survived MPC (n?=?556). All survivors completed questionnaires on health status (SF-36/European Organization of Research and Treatment of Cancer quality of life module), mental health (Hospital Anxiety and Depression Scale) and impact of cancer (Impact of Cancer). RESULTS: Compared with single primary cancer survivors, MPC survivors reported significantly poorer scores on general health and higher symptom scores on diarrhoea and fatigue. Significantly more MPC survivors met the subclinical cut-off score of ?8 points on the Hospital Anxiety and Depression Scale depression subscale (27% vs. 19%, p?=?0.0001). MPC survivors also reported significantly greater negative impact of cancer (namely body changes and life interferences) and positive impact of health awareness on their lives. All results were adjusted for age at survey, time since last diagnosis, sex, comorbidity, body mass index and marital status. In secondary analyses, MPC survivors with different primary cancer combinations or time interval between primary cancer diagnoses had comparable health status and psychosocial well-being. CONCLUSION: Multiple primary cancer survivors reported a poorer health status and, in general, experienced a greater negative impact of cancer on their psychosocial well-being than single primary cancer survivors. Copyright © 2012 John Wiley & Sons, Ltd.
HubMed – depression


Corrections to “forecasting depression in bipolar disorder”.

Filed under: Depression Treatment

IEEE Trans Biomed Eng. 2012 Dec; 59(12): 3550
Moore PJ, Little MA, McSharry PE, Geddes JR, Goodwin GM

HubMed – depression


The utility of the PHQ-9 to assess suicide risk in patients with systemic sclerosis.

Filed under: Depression Treatment

Arthritis Care Res (Hoboken). 2012 Nov 30;
Razykov I, Hudson M, Baron M, Thombs BD,

OBJECTIVE.: Item 9 of the Patient Health Questionnaire-9 (PHQ-9), which inquires about both passive thoughts of death and active ideas of self-harm, has been used to assess suicide risk in arthritis. The objectives of this study were (1) to determine the proportion of systemic sclerosis (SSc) patients who responded “yes” to Item 9 who endorsed active suicidal ideation in response to more direct questions during a structured clinical interview and (2) to report whether the PHQ-8, which does not include Item 9 from the PHQ-9, performs similarly to the PHQ-9. METHODS.: Patients were recruited from the Canadian Scleroderma Research Group Registry. The PHQ-9 and Composite International Diagnostic Interview (CIDI) depression module wereadministered during a phone interview. Scores on the PHQ-8 were calculated by removingItem 9 from the PHQ-9. Item 9 responses were compared to suicidal ideation and intent in the last year based on the CIDI. Scores on the PHQ-8 and PHQ-9 were compared using Pearson correlations. RESULTS.: There were 345 patients interviewed, of whom 31(9.0%) endorsed Item 9 of the PHQ-9. Of those, based on the CIDI, 14 (45.2%) had passive thoughts of suicide or death. Only 1 (3.2%) had thought about suicide in some detail at any point in the last 12 months. The correlation between PHQ-9 and PHQ-8 scores was r=0.998. CONCLUSION.: Item 9 appears to identify many patients who do not report active suicidal ideation. The PHQ-8 may be a better option for assessment of depressive symptoms than the PHQ-9 in SSc patients. © 2012 by the American College of Rheumatology.
HubMed – depression



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