Methotrexate-Induced Pulmonary Toxicity.

Methotrexate-induced pulmonary toxicity.

Can Respir J. 2013 May-Jun; 20(3): 153-5
Jakubovic BD, Donovan A, Webster PM, Shear NH

Methotrexate is a widely used medication with an array of recognized side effects. The present report describes a case of methotrexate-induced pneumonitis in a patient with psoriasis, and demonstrates the hallmark clinical and investigational findings that support this infrequently encountered diagnosis. The ensuing discussion reviews the pathogenesis, management and prevention of this adverse drug reaction. HubMed – drug


The novel oral drug subetta exerts an antidiabetic effect in the diabetic goto-kakizaki rat: comparison with rosiglitazone.

J Diabetes Res. 2013; 2013: 763125
Bailbé D, Philippe E, Gorbunov E, Tarasov S, Epstein O, Portha B

The aim of the present study was to evaluate the potential antidiabetic effects of two-component drug Subetta and its components (release-active dilutions of antibodies to ? -subunit insulin receptor (RAD of Abs to ? -InsR) and to endothelial nitric oxide synthase (RAD of Abs to eNOS)) in Goto-Kakizaki (Paris colony) (GK/Par) diabetic rats. Subetta was administered orally for 28 days once daily (5?mL/kg) and compared to its two components (2.5?mL/kg), Rosiglitazone (5?mg/kg), and vehicle (5?mL water/kg). At day 28, fasting plasma glucose levels were significantly decreased only in Subetta and Rosiglitazone groups as compared to vehicle (P < 0.01): 147 ± 4?mg/dL and 145 ± 4?mg/dL and 165 ± 4?mg/dL, respectively. The data of glucose tolerance test showed that Subetta and RAD of Abs to ? -InsR (similar to Rosiglitazone) prevented significantly (P < 0.01) the age-related spontaneous deterioration of glucose tolerance as seen in the control group. Subetta and RAD of Abs to ? -InsR did not significantly modify the glucose-induced insulin secretion. Chronic administration of Subetta and RAD of Abs to ? -InsR improves glucose control, to an extent similar to that of Rosiglitazone. We hypothesize that Subetta and RAD of Abs to ? -InsR mostly act via an insulin-sensitizing effect upon target tissues. HubMed – drug


Adipokines and hepatic insulin resistance.

J Diabetes Res. 2013; 2013: 170532
Li Y, Ding L, Hassan W, Abdelkader D, Shang J

Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-?, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it. HubMed – drug