Major Depression in Young Girls Is Related to Altered Cortisol Awakening Response.

Major depression in young girls is related to altered cortisol awakening response.

Filed under: Depression Treatment

Eur Child Adolesc Psychiatry. 2013 Jan 5;
Ulrike S, Reinhold L, Dirk H

BACKGROUND: There is evidence that clinical depression is associated with elevated basal cortisol levels in adult patients. OBJECTIVE: The present investigation tries to find out, whether this relationship also holds true in adolescents with major depression. METHODS: For 131 female subjects (63 MDD, 68 controls) the cortisol awakening response (CAR) was measured at 0, 30, 45, and 60 min after awakening. All subjects provided saliva cortisol. RESULTS: A significantly higher CAR was found in patients. The global mean difference was due to differences 60 and 45 min after awakening. LIMITATIONS: A causal interpretation of the data is restricted, because of its cross-sectional nature. The effect size of the mean differences is rather small. CONCLUSION: The observed HPA hyperactivity may be a cause as well as a consequence of depression in childhood.
HubMed – depression


Depression and anxiety among parents and caregivers of autistic spectral disorder children.

Filed under: Depression Treatment

Neurosciences (Riyadh). 2013 Jan; 18(1): 58-63
Almansour MA, Alateeq MA, Alzahrani MK, Algeffari MA, Alhomaidan HT

To evaluate the presence of depression and anxiety in parents/caregivers of autistic spectral disorder (ASD) children, and to identify associated factors.In this retrospective cohort study carried out between July and December 2011, parents/caregivers of at least one child diagnosed with an ASD (cases group), were recruited through the Saudi Charitable Society of Autism Families and the Autism Clinic in the Pediatric out-patient clinic in King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Riyadh, Kingdom of Saudi Arabia. The parents/caregivers of a normally developed child (control group) were recruited from the Well Child Clinic at King Abdulaziz Medical City, Riyadh. We used a self-reported questionnaire containing questions on demographic data, as well as the Arabic version of the hospital anxiety and depression scale.The study included 100 parents/caregivers, 50 cases and 50 controls. More than 50% of the control group was in the age group 26-30 years (56%), while 42% of cases were in the age group 31-35 years. Time lapsed since autism diagnosis was over 3 years in one-third of cases. Twenty-two percent of cases, and only 2% of control parents/caregivers had a history of psychiatric problems (p=0.002). Both the mean depression score, and the mean anxiety score was significantly higher among cases when compared with controls, p<0.001.Autism is associated with burden and stress for parents/caregivers of the affected child. The demands placed by the disability contribute to a higher overall incidence of depression and anxiety among parents/caregivers. HubMed – depression


Transient Hemiparesis (Todd’s Paralysis) After Electroconvulsive Therapy (ECT) in a Patient With Major Depressive Disorder.

Filed under: Depression Treatment

J ECT. 2013 Jan 3;
Liff JM, Bryson EO, Maloutas E, Garruto K, Pasculli RM, Briggs MC, Kellner CH

ABSTRACT: We report the case of a 50-year-old man who exhibited transient left hemiparesis (Todd’s paralysis) after electroconvulsive therapy, which completely resolved within 10 minutes. Subsequent neurological evaluation was unremarkable for discrete etiologies for this event, other than Todd’s paralysis. We review the literature of this phenomenon in association with electroconvulsive therapy.
HubMed – depression


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