Identifying Biomarkers and Drug Targets Using Systems Biology Approaches for Pancreatic Cancer.

Identifying Biomarkers and Drug Targets Using Systems Biology Approaches for Pancreatic Cancer.

Filed under: Drug and Alcohol Rehabilitation

Pancreat Disord Ther. 2012 Dec 6; 2(4): 1000e128
Tan Y, Miele L, Sarkar FH, Wang Z

HubMed – drug

 

Use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release.

Filed under: Drug and Alcohol Rehabilitation

ISRN Pharm. 2012; 2012: 730624
Malakar J, Nayak AK, Goswami S

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.
HubMed – drug

 

Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans.

Filed under: Drug and Alcohol Rehabilitation

ISRN Pharm. 2012; 2012: 653465
Wagh VD, Deshmukh OJ

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant?:?cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesicle size, entrapment efficiency, and drug release were markedly dependent on surfactant?:?cholesterol ratio and quantity of ethanol used. Permeation of the drug through the skin was affected by cholesterol content in formulation. Itraconazole niosome were having larger zone of inhibition than marketed formulation when activity was checked against C. albicans. Niosomes may be a promising carrier for topical delivery of Itraconazole especially due to their simple production.
HubMed – drug

 

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