Genetic Architecture of Wistar Kyoto Rats (WKY) and Spontaneous Hypertensive Rats (SHR) Substrains From Difference Sources.

Genetic architecture of Wistar Kyoto rats (WKY) and Spontaneous hypertensive Rats (SHR) substrains from difference sources.

Physiol Genomics. 2013 May 14;
Zhang-James Y, Middleton FA, Faraone SV

The spontaneously hypertensive rat (SHR) has been widely used as a model for studies of hypertension and attention deficit/hyperactivity disorder (ADHD). The inbred Wistar-Kyoto (WKY) rat, derived from the same ancestral outbred Wistar rat as the SHR, are normotensive and have been used as the closest genetic control for the SHR, although the WKY has also been used as a model for depression. Notably, however, substantial behavioral and genetic differences among the WKY substrains, usually from the different vendors and breeders, have been observed. These differences have often been overlooked in prior studies, leading to inconsistent and even contradictory findings. The complicated breeding history of the SHR and WKY rats and the lack of a comprehensive understanding of the genetic background of different commercial substrains make the selection of control rats a daunting task, even for researchers who are mindful of their genetic heterogeneity. In this study, we examined the genetic relationship of 16 commonly used WKY and SHR rat substrains using genome-wide SNP genotyping data. Our results confirmed a large genetic divergence and complicated relationships among the SHR and WKY substrains. This understanding, although incomplete without the genome sequence, provides useful guidance in selecting substrains and helps to interpret previous reports when the source of the animals was known. Moreover, we found two closely related, yet distinct WKY substrains that may provide novel opportunities in modeling psychiatric disorders. HubMed – depression


Prevalence and correlates of major depressive episodes in Sousse primary care setting: Assessment with Tunisian version of CIDI.

Tunis Med. 2013 Apr; 91(4): 234-239
Amamou B, Elkissi Y, Braham A, Souhaiel Bannour A, Ben Rejeb M, Ben Nasr S, Mtiraoui A, Ben Hadj Ali B

Background: Major depression is a mental disorder that is associated with high morbidity and significant mortality. It is common among primary care attenders. Few is known about major depression prevalence and associated factors, which would prevent general practitioners from diagnosing it in primary care centres and treating it adequately. aim: To determine prevalence and correlates of major depressive episodes (MDE) in a representative sample of primary care attenders in the area of Sousse (Tunisia). methods: A random and representative sample of primary care attenders was obtained by a two-stage sampling procedure. First, 30 primary care centres (20 urban and 10 rural) were selected, with stratification according to residency location. Second, 1246 consenting participants were systematically recruited among those centres attenders. Participants were screened, by trained interviewers, with Tunisian version of « Composite International Diagnostic Interview » CIDI.2.1. After data entry in ishell program, MDE diagnosis was obtained according to ICD-10 criteria. Results: Mean age in our sample was 43.4 ± 17.62 years, with feminine (70.9 %) and urban (67.8 %) predominance. MDE was found in 26.4 % of participants. Associated factors were female gender, marital statute of widowed or divorced and rural residency. Conclusion: This study provided data about high prevalence of MDE in the area of Sousse primary care centres and its correlated factors. HubMed – depression