Evaluation of Serum Sodium Changes in Tricyclic Antidepressants Toxicity and Its Correlation With Electrocardiography, Serum pH, and Toxicity Severity.

Evaluation of serum sodium changes in tricyclic antidepressants toxicity and its correlation with electrocardiography, serum pH, and toxicity severity.

Filed under: Depression Treatment

Adv Biomed Res. 2012; 1: 68
Gheshlaghi F, Eizadi-Mood N, Emamikhah-Abarghooeii S, Arzani-Shamsabadi M

Tricyclic antidepressants (TCAs) is a group of drugs used for the depression treatment. One of the effects of these drugs is Na (sodium) channel blocking ability causing cardiac complications such as ventricular tachycardia and Torsades de pointes Arrhythmia. Sodium bicarbonate is used for treatment of these complications which may have some effect on serum sodium levels. Considering no specific research on Na changes on these patients, the serum Na changes and its correlation with ECG changes, serum pH, and TCA toxicity severity were evaluated.A prospective descriptive-analytic cross-sectional study was done on TCA-poisoning patients who were admitted in Noor hospital in Esfahan in last 2 years. Serum sodium levels, ECG changes, and TCA severity toxicity of 92 patients were evaluated five times during first 24 h of admission.A total of 92 patients were studied. The most common symptoms were conscious level changes (81.52%) and mydriasis (64.1%). Based on toxicity severity by these symptoms the patients were classified into three groups: 12% of the patients had mild toxicity, 50% moderate, and 38% severe toxicity. There were no significant differences in mean serum Na during the time. There was not found any correlation between serum Na level, and serum pH, ECG, and toxicity severity.Using sodium bicarbonate in TCA-poisoning cases does not change the serum Na levels significantly.
HubMed – depression


Acute myocardial infarction caused by filgrastim: a case report.

Filed under: Depression Treatment

Case Rep Oncol Med. 2012; 2012: 784128
Bilir C, Engin H, Temi YB, Toka B, Karaba? T

Common uses of the granulocyte-colony stimulating factors in the clinical practice raise the concern about side effects of these agents. We presented a case report about an acute myocardial infarction with non-ST segment elevation during filgrastim administration. A 73-year-old man had squamous cell carcinoma of larynx with lung metastasis treated with the chemotherapy. Second day after the filgrastim, patient had a chest discomfort. An ECG was performed and showed an ST segment depression and negative T waves on inferior derivations. A coronary angiography had showed a critical lesion in right coronary arteria. This is the first study thats revealed that G-CSF can cause acute myocardial infarction in cancer patients without history of cardiac disease. Patients with chest discomfort and pain who are on treatment with G-CSF or GM-CSF must alert the physicians for acute coronary events.
HubMed – depression


Quality of life in bipolar type I disorder in a one-year followup.

Filed under: Depression Treatment

Depress Res Treat. 2012; 2012: 860745
Amini H, Sharifi V

Objectives. The aims of this study were (i) to compare Quality of Life (QOL) of patients with bipolar disorder (BD) type I to those with schizophrenia during a one-year period after hospitalization and (ii) to assess the association of different domains of QOL with severity of clinical symptoms and level of functioning in bipolar patients group. Method. A hundred and two participants were consecutively recruited before discharge from an acute hospitalization. To measure QOL as the main outcome variable, the Farsi (Persian) version of the World Health Organization’s QOL Instrument Short Version (WHOQOL BREF) was used. Affective symptoms, overall functioning, and severity of mental illness were assessed as well. The assessment procedure was repeated four, eight, and 12 months after discharge. Results. No significant differences were found between patients with BD and schizophrenia on four domains of WHOQOL BREF at the baseline and the four, eight, and 12 month assessments. Within the subjects with bipolar I disorder, the most stable finding was negative association of depression severity with WHOQOL-BREF on the all four domains during repeated assessments. Conclusion. The findings suggest that persistent depressive symptoms might be the primary determinant of impaired QOL in patients with bipolar I disorder.
HubMed – depression


Amoryn – Depression & Anxiety
AMORYN works by increasing the levels of all four of the brain’s “feel good” neurotransmitters. By providing an all-natural boost …

Dealing with Depression Naturally : Alternatives and Complementary Therapies for Restoring Emotional Health
From the cutting edge of natural antidepressant research, here is new information on St. John’s wort, SAMe, bright light therapy, …

Overcoming Depression in Teens and Pre-Teens: A Parent’s Guide (Dr. T’s Living Well Series)
The treatment modalities for pre-teen and teenager depression require a multi-factorial approach. Cognitive-behavioral therapy in …

Find More Depression Treatment Information…