Evaluation of Effect of Allopurinol and Febuxostat in Behavioral Model of Depression in Mice.

Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice.

Indian J Pharmacol. 2013 May; 45(3): 244-7
Karve AV, Jagtiani SS, Chitnis KA

To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21(st) day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity. HubMed – depression


Use of Electroconvulsive Therapy in the Presence of GLAUCOMA: A Case Report and Review of Literature.

Indian J Psychol Med. 2013 Jan; 35(1): 80-3
Aneja J, Grover S, Agarwal M, Kaushik S

Limited data is available with respect to use of Electroconvulsive therapy (ECT) in the presence of glaucoma. We present a case of severe depression with psychotic symptoms who did not respond to various antidepressant trials and required ECT. His medical history showed that he was diagnosed to have open angle glaucoma and cataract in both the eyes. He had undergone bilateral trabeculectomy and cataract surgery for his ophthalmological aliments. He was safely treated with bilateral ECT, with which he achieved remission. HubMed – depression


Anxiety disorders in bipolar I mania: prevalence, effect on illness severity, and treatment implications.

Indian J Psychol Med. 2013 Jan; 35(1): 53-9
Das A

Comorbidity in bipolar disorder (BP) is common, of which anxiety disorder (AD) comorbidity has received recent attention. The aim of the present study was to find the prevalence of (current and lifetime) ADs in BP I with recent episode mania, its effect on illness severity and its treatment implications. This is unlike the convention of associating “anxiety” with depression. Here, the hierarchical diagnostic criterion of the DSM IV-TR was suspended for heuristic purpose.Consecutively admitted 102 consenting in-patients of bipolar mania were evaluated on Young Mania Rating Scale, Brief Psychiatric Rating Scale, and Hamilton Rating Scale for Anxiety, at baseline and after 45 days. When the patient became cooperative, Schedule for Affective Disorders and Schizophrenia – the lifetime version interview AD section, was conducted. Protocol for management of current acute state was kept flexible and naturalistic. All treatment details, historical bipolar illness and socio-demographic variables were collected from case record file and unstructured interview with patient and caregiver.High prevalence of lifetime (70.2 percent) and moderate levels of current (29.6 percent) comorbid ADs were found. Comorbid lifetime AD was associated with more severe BP course (more past depressive episodes (P<0.001), less inter-episode recovery (P<0.01), and poorer response to acute phase treatment). Comorbid AD group needed more number of mood stabilizers for acute management (P<0.05).Findings illustrate the importance of this comorbidity having implications for psychiatric diagnostic systems. HubMed – depression


Assessing perceived stress in medical personnel: in search of an appropriate scale for the bengali population.

Indian J Psychol Med. 2013 Jan; 35(1): 29-33
Chakraborti A, Ray P, Sanyal D, Thakurta RG, Bhattacharayya AK, Mallick AK, Das R, Ali SN

The occurrence of stress and stress related anxiety and depression in medical personnel are being increasingly reported in literature. The perceived stress scale (PSS) is the most widely used psychological instrument for measuring the perception of stress. It is needed to assess perceived stress in our population using appropriately translated version of PSS. The objectives of study were to prepare a Bengali version of PSS-10 and to establish its psychometric properties in the study population.The study was conducted in a teaching hospital among medical students and interns (N=37). The translated Bengali version and the original English version of PSS-10 were separately handed over to the individual subjects. The scores were compared across different subgroups and psychometric properties of the translated version were assessed using SPSS 16.Internal consistency of PSS English (?=0.79) and Bengali (?=0.80) was satisfactory. Intra-rater reliability was adequate (?>0.5) for most of the items, but showed an inadequate value (?<0.5) for four items on the scale. After deleting these four items from the Bengali version, a new six-item PSS in Bengali was derived that showed good internal consistency (?=0.699).This new version needs to be validated in a larger study population. Perceived stress score using PSS-10 was considerably high in our study population, although there was no significant difference between the subgroups (male/female, intern/student). HubMed – depression



A Look At Different Depression Treatment Regimens – Voice Article – A Look At Different Depression Treatment Regimens One of the most prevalent health problem in many countries around the world is depression. Indeed, research…