ERRATUM: The Regulatory Role of Long-Term Depression in Juvenile and Adult Mouse Ocular Dominance Plasticity.

ERRATUM: The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity.

Sci Rep. 2013 Apr 2; 3: 1442
Yang K, Xiong W, Yang G, Kojic L, Taghibiglou C, Wang YT, Cynader M

HubMed – depression


Treatment course with antidepressant therapy in late-life depression.

Am J Psychiatry. 2013 Apr 1; 170(4): 446
Irion KL, Muly S, Hochhegger B, Marchiori E

HubMed – depression


Effects of pharmacologically induced hypogonadism on mood and behavior in healthy young women.

Am J Psychiatry. 2013 Apr 1; 170(4): 426-33
Ben Dor R, Harsh VL, Fortinsky P, Koziol DE, Rubinow DR, Schmidt PJ

OBJECTIVE The relationship between depression and estrogen withdrawal remains controversial. The authors examined the effects of gonadotropin-releasing hormone agonist-induced ovarian suppression on mood, sleep, sexual function, and nighttime hot flushes. They focused on whether participating women experienced clinically significant depressive symptoms and whether specific symptoms associated with hypogonadism (nighttime hot flushes and disturbed sleep) increased susceptibility to depression. METHOD Participants were 72 healthy premenopausal women, ages 19-52 years, with no current or past axis I psychiatric diagnosis or gynecological or other medical illness. After 2 months of baseline screening, women received monthly injections of leuprolide acetate (3.75 mg) for 2-3 months. Outcomes were measured using the Beck Depression Inventory (BDI) and a daily rating scale measuring the severity of several affective and behavioral symptoms. Data were analyzed by repeated-measures analysis of variance using PROC MIXED (for mixed models). RESULTS BDI scores ?10 were reported in four of the 72 women (5.6%). Relative to baseline, induced hypogonadism was associated with significantly decreased sexual interest, disturbed sleep, and more severe nighttime hot flushes, but no significant change in any mood-related symptom score. Hot flush severity was significantly correlated with disturbed sleep. CONCLUSIONS These data demonstrate that clinically significant depressive symptoms were rare accompaniments of short-term estradiol withdrawal and induced hypogonadism in healthy premenopausal women. Additionally, neither nighttime hot flushes nor disturbed sleep were sufficient to cause depressive symptoms in hypogonadal women. HubMed – depression


Severe bradycardia caused by a single dose of lithium.

Intern Med. 2013; 52(7): 767-9
Sabharwal MS, Annapureddy N, Agarwal SK, Ammakkanavar N, Kanakadandi V, Nadkarni GN

Lithium is used as a mood stabilizer in patients with manic-depressive disorder. It is a drug that requires close monitoring due to its narrow therapeutic window and many side effects. There are several case reports of lithium side effects and toxicity occurring even at the therapeutic levels. Cardiac toxicity is observed in approximately 5% of patients; however, severe bradycardia caused by a single dose of lithium is exceedingly rare. We herein report a case of severe symptomatic bradycardia in a young man that occurred after a single dose of lithium. This case emphasizes the need to closely monitor patients when initiating therapy, even before the lithium levels are high enough to be detected. HubMed – depression



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