Efficacy of Ketoprofen Administered in Drinking Water at a Low Dose for the Treatment of Porcine Respiratory Disease Complex.

Efficacy of ketoprofen administered in drinking water at a low dose for the treatment of Porcine Respiratory Disease Complex.

J Anim Sci. 2013 Jul 3;
Salichs M, Sabaté D, Homedes J

The purpose of this study was to evaluate the efficacy of an oral solution of ketoprofen administered in drinking water at a lower dose as a complement to antimicrobial therapy in a mild outbreak of Porcine Respiratory Disease Complex. The study was performed with 120 pigs with rectal temperature between 39.9 and 41°C and at least one sign indicating Porcine Respiratory Disease Complex (dyspnea, cough, nasal discharge, depression). Animals were randomly allocated in two groups (treated and control group). Animals in both groups received etiological therapy with doxycycline at 10 mg kg(-1) in drinking water for 5 d. The animals in the treated group also received 1.5 mg kg(-1) of ketoprofen during the first 3 d. The reduction in rectal temperature in the treated group was significantly greater during the days of ketoprofen administration and up to one day after the end of treatment (P < 0.05). The percentage of dyspneic animals was significantly lower (P < 0.05) in the treated group from d 2 to 5 of the study. Also, a significant improvement regarding depression and cough was seen in the animals of the treated group. No statistically significant differences were evidenced in productive parameters. In conclusion, oral treatment with ketoprofen at 1.5 mg kg(-1) in combination with antimicrobial therapy was found to be a clinically effective approach in outbreaks of mild Porcine Respiratory Disease Complex. HubMed – depression