[Effect of Shuganjieyu Capsules on Neuronal Apoptosis in Hippocampal CA3 Area and the Expression of Caspase-3 in the Brain of Rat Depression Model].

[Effect of Shuganjieyu capsules on neuronal apoptosis in hippocampal CA3 area and the expression of caspase-3 in the brain of rat depression model].

Filed under: Depression Treatment

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Dec; 37(12): 1198-204
Fu J, Liu Y, Wang Q, Zhao J

Objective: To evaluate the effect of “Shuganjieyu” (SGJY) capsules on neuronal apoptosis in hippocampal CA3 area and the expression of caspase-3 in the brain of rat depression model, and to investigate its pharmacological mechanisms in depression treatment. Methods: Adult male SD rats were randomly divided into 4 groups: a control, a model, a SGJY and a fluoxetine group. The rat depression model was established under chronic unpredictable mild stress (CUMS) and separate feeding. The behaviors were measured by open-field test, sucrose consumption and forced swimming test. We observed the neuronal morphology structure and neuronal apoptosis in the hippocampal CA3 area. We detected the rat caspase-3 expression level of medial prefrontal cortex ( mPFC) and hippocampal CA3 area by Western blot. Results: After 21-day stress, compared with the model group, spontaneous activity and sucrose consumption and preference percentage of the rats in the SGJY group significantly increased, while the immobility time in forced swimming test, the number of apoptotic cells and the protein levels of caspase-3 significantly reduced (P<0.01 or 0.05). There was no significant difference between the SGJY group and the fluoxetine group (P>0.05). Conclusion: SGJY capsules can reduce the depression symptoms of CUMS and help to increase hippocampal neuron generation, survival and neogenesis, reduce the protein levels of caspase-3, and reverse neurocyte apoptosis in the rat depression model with the same efficacy as fluoxetine.
HubMed – depression


Cognitive behavioral self-help intervention reduces depression and anxiety and improves coping self-efficacy in people with rheumatism.

Filed under: Depression Treatment

Arthritis Care Res (Hoboken). 2012 Dec 21;
Garnefski N, Kraaij V, Benoist M, Bout Z, Karels E, Smit A

Objective – The aim of the study was to investigate whether a new cognitive-behavioral self-help program with minimal coaching could improve psychological well-being (depression, anxiety, and coping self-efficacy) in people with rheumatism and depressive symptoms. Methods – In total 82 persons with a rheumatic disease enrolled in a randomized controlled trial with two conditions: a group receiving the self-help program and a waiting list control condition. For both groups there were three measurement moments: baseline, posttest and follow-up. Outcome measures were the Depression and Anxiety scales of the Hospital Anxiety Depression Scale and an adaptation of the Generalized Self Efficacy Scale (GSES). Repeated measures Analyses of Covariance were performed to evaluate changes in the outcome measures from pretest to posttest and from posttest to follow-up. Results – The results showed that the self-help program was effective in reducing symptoms of depression and anxiety, and in strengthening coping self-efficacy. The positive effects remained after a follow-up period of two months. Conclusions – This cost-effective program could very well be used as a first step in a stepped-care approach or as one of the treatment possibilities in a matched care approach. © 2012 by the American College of Rheumatology.
HubMed – depression


Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9.

Filed under: Depression Treatment

Am J Med Genet B Neuropsychiatr Genet. 2012 Dec 31;
Ayub M, Irfan M, Maclean A, Naeem F, Blackwood D

A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression. © 2012 Wiley Periodicals, Inc.
HubMed – depression


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